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Particulate Matter Exposure, Prenatal and Postnatal Windows of Susceptibility, and Autism Spectrum Disorders
Background: Recent studies suggest that exposure to traffic-related air pollutants, including particulate matter (PM), is associated with autism spectrum disorder (autism). Methods: Children withExpand
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Detecting Association of Rare and Common Variants by Testing an Optimally Weighted Combination of Variants
Next‐generation sequencing technology will soon allow sequencing the whole genome of large groups of individuals, and thus will make directly testing rare variants possible. Currently, most ofExpand
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  • Open Access
A new association test to test multiple‐marker association
As a result of the availability of a very large numbers of single nucleotide polymorphisms, there has been increasing interest in genetic associations involving several closely linked loci. MethodsExpand
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Multistage designs in the genomic era: Providing balance in complex disease studies
In this summary paper, we describe the contributions included in the Multistage Design group (Group 14) at the Genetic Analysis Workshop 15, which was held during November 12–14, 2006. Our groupExpand
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Incorporating multiple-marker information to detect risk loci for rheumatoid arthritis
In genome-wide association studies, new schemes are needed to incorporate multiple-locus information. In this article, we proposed a two-stage sliding-window approach to detect associations between aExpand
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The genome of jojoba (Simmondsia chinensis): A taxonomically isolated species that directs wax ester accumulation in its seeds
New genomic resources for jojoba reveal insights into its phylogeny and the spatial differences of lipid synthesis and storage. Seeds of the desert shrub, jojoba (Simmondsia chinensis), are anExpand
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  • Open Access
Genome-wide association tests by two-stage approaches with unified analysis of families and unrelated individuals
Multiple testing is a problem in genome-wide or region-wide association studies. In this report, we consider a study design given by the Genetic Analysis Workshop 15 (GAW15) Problem 3 – nuclearExpand
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GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics
GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving aExpand
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Association of GSTM1 null variant with anthracycline-related cardiomyopathy after childhood cancer-A Children's Oncology Group ALTE03N1 report.
BACKGROUND Anthracycline-related cardiomyopathy is a leading cause of late morbidity in childhood cancer survivors. Glutathione S-transferases (GSTs) are a class of phase II detoxification enzymesExpand
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