Xuewen Chen

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We developed a mathematical model to simulate shear stress-dependent nitric oxide (NO) production and transport in a 3D microcirculatory network based on published data. The model consists of a 100 μm × 500 μm × 75 μm rectangular volume of tissue containing two arteriole-branching trees, and nine capillaries surrounding the vessels. Computed distributions(More)
Opinion mining is an important research topic in data mining. Many current methods are coarse-grained, which are practically problemic due to insufficient feedback information and limited reference values. To address these problems, a novel topic and sentiment unification maximum entropy LDA model is proposed in this paper for fine-grained opinion mining of(More)
Protein synthetic lethal genetic interactions are useful to define functional relationships between proteins and pathways. However, the molecular mechanism of synthetic lethal genetic interactions remains unclear. In this study we used the clusters of short polypeptide sequences, which are typically shorter than the classically defined protein domains, to(More)
High throughput technologies such as microarray have produced huge amount of genomic and proteomic data in public domain. Many survey and clinical outcome data such as SEER data are also available. A long list of links to large health-related data sets can be found at the website http://www.ehdp.com/. All of these databases have different temporal and(More)
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