Xuewei Yang

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Metastasis is responsible for the rapid recurrence and poor survival of malignancies. Epithelial-mesenchymal transition (EMT) has a critical role in metastasis. Increasing evidence indicates that EMT can be regulated by microRNAs (miRNAs). The aim of this study was to investigate the role of miR-26b in modulating epithelial-mesenchymal transition (EMT) in(More)
BACKGROUND Our previous studies showed that glioma-associated oncogene (Gli)2 plays an important role in the proliferation and apoptosis resistance of hepatocellular carcinoma (HCC) cells. The aim of this study was to explore the clinical significance of Gli2 expression in HCC. METHODS Expression of Gli2 protein was detected in samples from 68 paired HCC(More)
Hepatocellular carcinoma (HCC) is one of the common malignancies, which is highly metastatic and the third common cause of cancer deaths in the world. The invasion and metastasis of cancer cells is a multistep and complex process which is mainly initiated by extracellular matrix (ECM) degradation. Aberrant expression of microRNA has been investigated in HCC(More)
JEL classification: G22 G33 MSC: 91B30 60J75 60H10 Keywords: Risk model Barrier strategy Lévy process Two-sided jump Time of ruin Deficit Expected discounted dividend Optimal dividend barrier Integro-differential operator Double exponential distribution Reflected jump-diffusions Laplace transform a b s t r a c t In this paper, we consider a general Lévy(More)
A distributed map data parallel dissemination system, which can be used to distribute spatial map data to remote users through different networks, is presented. The paper first defines spatial map data, associated metadata and network resource nodes with graphic formalization definition. Then, the relations between map data and network resources are(More)
We examine the notion that financial innovations cater to investors' behavioral biases. Specifically, we analyze the popularity of callable bull/bear contracts (CBBCs), which are options that can be called back when underlying prices reach a threshold. Investors treat CBBCs like lotteries in that they prefer CBBCs with low prices, high volatilities, and(More)
We have screened 11 isoquinoline derivatives and α-methylene-γ-butyrolactones using the 3-(4,5-dimethylthi-azol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay in HeLa and HEK-293T cells. Compound 2 was identified as potential anticancer agent. To further improve its therapeutic potential, this agent was incorporated into transferrin(More)
The pre-mRNA splicing regulator serine-arginine protein kinase 1 (SRPK1) promotes cancer development and various pathophysiological processes. However, the clinical relevance of SRPK1 in hepatocellular carcinoma (HCC) is not clear. This study investigates the expression and prognostic value of SRPK1 in HCC. We found that SRPK1 expression was significantly(More)