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1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells*
- Z. Ryan, T. Craig, +8 authors R. Kumar
- Biology, Medicine
- The Journal of Biological Chemistry
- 24 November 2015
Muscle weakness and myopathy are observed in vitamin D deficiency and chronic renal failure, where concentrations of the active vitamin D3 metabolite, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), are… Expand
Loss of FAM46C Promotes Cell Survival in Myeloma.
FAM46C is one of the most recurrently mutated genes in multiple myeloma; however its role in disease pathogenesis has not been determined. Here we demonstrate that wild-type (WT) FAM46C… Expand
Relationship between key environmental factors and profiling of volatile compounds during cucumber fruit development under protected cultivation.
- Xvzhen Li, Yinhui Sun, +4 authors Shuxia Chen
- Environmental Science, Medicine
- Food chemistry
- 4 May 2019
To provide precision management of cucumber under protected cultivation, the relationships between environmental factors and daily increment of aroma in two lines were analyzed during development,… Expand
Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.
In this study, we reported millepachine (MIL), a novel chalcone compound for the first time isolated from Millettia pachycarpa Benth (Leguminosae), induced cell cycle arrest and apoptosis in human… Expand
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
- S. S. Kang, Mark T. W. Ebbert, +6 authors J. Fryer
- Biology, Medicine
- The Journal of experimental medicine
- 3 September 2018
Alzheimer’s disease (AD) is an age-associated neurodegenerative disease characterized by amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells. We show that a… Expand
miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and causes a high rate of mortality in affected adults. Many subtypes of ALL exist with disruptions in distinct genetic… Expand
Translational profiling of microglia reveals artifacts of cell sorting
Microglia are the resident innate immune population of the central nervous system that constantly survey and influence their local environment. Transcriptomic profiling has led to significant… Expand
Dek40 Encodes a PBAC4 Protein Required for 20S Proteasome Biogenesis and Seed Development1
The PBAC4 chaperone encoded by Dek40 in maize influences 20S core protease biogenesis and is required for 26S proteasome function and seed development. The 26S proteasome, an essential protease… Expand
Enhancement of Inducible Nitric Oxide Synthase Activity by Low Molecular Weight Peptides Derived from Protamine: A Potential Therapy for Chronic Rhinosinusitis.
- Anant S Balijepalli, Adam T. Comstock, +5 authors M. Meyerhoff
- Biology, Medicine
- Molecular pharmaceutics
- 2 June 2015
Nitric oxide (NO) is a key immune defense agent that is produced from l-arginine in the airways by leukocytes and airway epithelial cells, primarily via inducible nitric oxide synthase (iNOS).… Expand
Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity…
- Liang Ma, J. Chen, +10 authors L. Chen
- Chemistry, Medicine
- Journal of medicinal chemistry
- 8 September 2011
Honokiol, widely known as an antitumor agent, has been used as an antiangiogenesis drug lead. In this paper, 47 honokiol analogues and derivatives were investigated for their antiangiogenic activity… Expand