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RNA interference (RNAi) has been developed as a powerful technique in the research of functional genomics as well as plant pest control. In this report, double-stranded RNAs (dsRNA) targeting 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) gene, which catalyze a rate-limiting enzymatic reaction in the mevalonate pathway of juvenile hormone (JH)(More)
The computer keyboard is one of the most common, reliable, accessible, and effective tools used for human--machine interfacing and information exchange. Although keyboards have been used for hundreds of years for advancing human civilization, studying human behavior by keystroke dynamics using smart keyboards remains a great challenge. Here we report a(More)
Plug-in hybrid vehicles (PHEVs) have great potential in reducing energy consumption and pollutant emissions, due to the use of electric batteries as another energy source. One of the critical considerations in PHEV development is the design of its energy management strategy, which determines how energy flows in a hybrid powertrain should be managed in(More)
The energy management system (EMS) is crucial to a plug-in hybrid electric vehicle (PHEV) in reducing its fuel consumption and pollutant emissions. The EMS determines how energy flows in a hybrid powertrain should be managed in response to a variety of driving conditions. In the development of EMS, the battery state-of-charge (SOC) control strategy plays a(More)
Plug-in hybrid electric vehicles (PHEVs) show great promise in reducing transportation-related fossil fuel consumption and greenhouse gas emissions. A critical research topic for PHEVs is designing an efficient energy management system (EMS), in particular, determining how the energy flows in a hybrid powertrain should be managed in response to a variety of(More)
Plug-in hybrid electric vehicles (PHEVs) have been regarded as one of several promising countermeasures to transportation-related energy use and air quality issues. Compared with conventional hybrid electric vehicles, developing an energy management system (EMS) for PHEVs is more challenging due to their more complex powertrain. In this paper, we propose a(More)
The p53 mutation and altered Pten expression are two most common genetic events in Hepatitis B virus (HBV) infection related hepatocellular carcinoma (HCC). To confirm the causative role of p53 and Pten somatic mutation in HCC development, we established CRISPR/Cas9-mediated somatic gene disruption via hydrodynamic tail vein injection, allowing for in vivo(More)
In the past several decades, various types of technologies have been developed to improve vehicle fuel efficiency and reduce tailpipe emissions across different dimensions. For example, powertrain-related technologies improve fuel efficiency by optimizing the powertrain operations in response to different driving conditions (e.g., energy management system(More)