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Oxygen is critical to aerobic metabolism, but excessive oxygen (hyperoxia) causes cell injury and death. An oxygen-tolerant strain of HeLa cells, which proliferates even under 80% O2, termed "HeLa-80," was derived from wild-type HeLa cells ("HeLa-20") by selection for resistance to stepwise increases of oxygen partial pressure. Surprisingly, antioxidant(More)
BACKGROUND Magnesium sulfate has been used as an anticonvulsant in severe preeclamptic or eclamptic women prior to surgical trauma, but its effects on neuroinflammation is not well defined. In the present study, we investigated the neuroprotective effects of magnesium sulfate in lipopolysaccharide (LPS)-induced microglia and explored the underlying(More)
This kind of wall cleaning robot has two wheels that can be driven respectively, two vacuum pumps, and one negative suction disc with one mechanic-servo air-sealed ring. Some key techniques on kinematics and hydrodynamics of the robot are proposed in this paper. Aimed at the actual situations for wall cleaning works, this paper presented a sort of physical(More)
This paper presents a small-sized wall climbing robot for anti-terror and rescue scout tasks, which takes advantage of a method called critical suction. In this paper the critical suction mechanism is discussed in theory. Furthermore, the fluid model of the robot's suction system is set up using the fluid network theory. According to the dynamic response(More)
A novel robotic assistive rehabilitation system for both lower-limbs and upper-limbs muscle rehabilitation to general paralysis or quadriplegia and paraplegia patients has been developed. The system is featured with the ability to drive patients to do active and passive exercises which are the most important exercises for the limb weakness from early(More)
Exposure of mammals to hyperoxia causes pulmonary and ocular pathology. Hyperoxic damage and cell death may derive from enhanced intracellular formation of reactive oxygen species (ROS), probably of mitochondrial origin. There is, however, controversy on this point. When wild-type and respiration-deficient (rho(o)) HeLa cells were cultured in 80% O2,(More)
Chronic iron overload has slow and insidious effects on heart, liver, and other organs. Because iron-driven oxidation of most biologic materials (such as lipids and proteins) is readily repaired, this slow progression of organ damage implies some kind of biological "memory." We hypothesized that cumulative iron-catalyzed oxidant damage to mtDNA might occur(More)
In patients with hemochromatosis, cardiac dysfunction may appear years after they have reached a state of iron overload. We hypothesized that cumulative iron-catalyzed oxidant damage to mitochondrial DNA (mtDNA) might explain the cardiomyopathy of chronic iron overload. Mice were given repetitive injections of iron dextran for a total of 4weeks after which(More)
The differential drive two-wheeled inverted pendulum mobile robot has advantage of high maneuverability on slopes and in narrow spaces. It can be used to carry human beings as well as other goods. This paper mainly discusses mechanical design and dynamic modeling of this type of mobile robot platform. The first prototype is 12 kg of weight with dimensions(More)