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LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis.

• Shi-Dong Ma, Xuequn Xu, +9 authors Shannon C. Kenney
• The Journal of clinical investigation
• 2015

Epstein-Barr virus (EBV) infection transforms B cells in vitro and is associated with human B cell lymphomas. The major EBV oncoprotein, latent membrane protein 1 (LMP1), mimics constitutively active… (More)

PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model.

• Shi-Dong Ma, Xuequn Xu, +5 authors Shannon C. Kenney
• PLoS pathogens
• 2016

Epstein-Barr virus (EBV) infection causes B cell lymphomas in humanized mouse models and contributes to a variety of different types of human lymphomas. T cells directed against viral antigens play a… (More)

Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs.

• Xuequn Xu, Ginger M. Pocock, +9 authors Jenny E Gumperz
• Cell reports
• 2016

Invariant natural killer T (iNKT) cells are innate T lymphocytes that promote host defense against a variety of microbial pathogens. Whether microbial ligands are required for their protective… (More)

A DNA Vaccine Protects Human Immune Cells against Zika Virus Infection in Humanized Mice

• Guohua Yi, Xuequn Xu, +5 authors Narasimaswamy Manjunath
• EBioMedicine
• 2017

A DNA vaccine encoding prM and E protein has been shown to induce protection against Zika virus (ZIKV) infection in mice and monkeys. However, its effectiveness in humans remains undefined. Moreover,… (More)

Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model.

• Nicholas A Zumwalde, Akshat Sharma, +7 authors Jenny E Gumperz
• JCI insight
• 2017

A central issue for adoptive cellular immunotherapy is overcoming immunosuppressive signals to achieve tumor clearance. While γδ T cells are known to be potent cytolytic effectors that can kill a… (More)

Development of Anti-Human Mesothelin-Targeted Chimeric Antigen Receptor Messenger RNA-Transfected Peripheral Blood Lymphocytes for Ovarian Cancer Therapy.

• Chien Fu Hung, Xuequn Xu, +8 authors Leisha A. Emens
• Human gene therapy
• 2018

CD19-targeted chimeric antigen receptor (CAR) engineered T/natural killer (NK)-cell therapies can result in durable clinical responses in B-cell malignancies. However, CAR-based immunotherapies have… (More)

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