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PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/Erk-dependent pathways.
Cisplatin (CDDP) and CDDP-based combination chemotherapy have been confirmed effective against gastric cancer. However, CDDP efficiency is limited due to development of drug resistance. In thisExpand
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PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways
CDDP [cisplatin or cis-diamminedichloroplatinum(II)] and CDDP-based combination chemotherapy have been confirmed effective against gastric cancer. However, CDDP efficiency is limited because ofExpand
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Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer.
SIRT3 is a NAD(+)-dependent histone deacetylaseand and plays a critical role in various human carcinomas. However, its precise role in the pathogenesis of gastric cancer (GC) is still unclear.Expand
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