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Signal transducer and activator of transcription (Stat) 3 is an oncogene constitutively activated in many cancer systems where it contributes to carcinogenesis. To develop chemical probes that selectively target Stat3, we virtually screened 920,000 small drug-like compounds by docking each into the peptide-binding pocket of the Stat3 SH2 domain, which(More)
A six-generation Chinese family with autosomal dominant retinitis pigmentosa (adRP) was identified and characterized. Genome-wide linkage analysis linked the family to markers D19S601 to D19S605, which span the PRPF31 gene on chromosome 19q13.33-13.43 (RP11) (LOD=5.03). Direct DNA sequence analysis identified a novel splicing mutation (IVS1+1G>T) in(More)
Acute myeloid leukemia (AML) is the most common malignant myeloid disorder of progenitor cells in myeloid hematopoiesis and exemplifies a genetically heterogeneous disease. The patients with AML also show a heterogeneous response to therapy. Although all-trans retinoic acid (ATRA) has been successfully introduced to treat acute promyelocytic leukemia (APL),(More)
A novel lipase gene, lipJ08, was cloned from Candida rugosa ATCC14830, along with the already reported five lipase genes (lip1-lip5). Nucleotide sequencing indicated that the lipJ08 gene contains a 1650 bp open reading frame (ORF) without introns. The deduced amino acid sequence corresponds to 534 amino acid residues, including a putative signal sequence of(More)
We extend the group decoding algorithm [1] for space time block code (STBC) to the non-binary low density parity check code (LDPC) with Quasi-Orthogonal STBC in multiple-input and multiple-output (MIMO) system. A Gaussian based detection is proposed to reduce the decoding complexity in this paper. The complexity involved grows linearly with the number of(More)
Aspergillus niger lipases are important biocatalysis widely used in industries for food processing and pharmaceutical preparation. High-level expression recombinants can lead to cost effective lipase large scale production. Full length gene synthesis is an efficient measure to enhance the expression level of the gene. In order to reduce the non-specific(More)
Association rules can mine the relevant evidence of computer crime from the massive data and association rules among data itemset, and further mine crime trends and connections among different crimes. They can help polices detect case and prevent crime with clues and criterions. Frequent itemset mining (FIM) plays a fundamental role in mining associations,(More)
In this paper, a fully automatic method is proposed to segment the kidney into multiple components: renal cortex, renal column, renal medulla and renal pelvis, in clinical 3D CT abdominal images. The proposed fast automatic segmentation method of kidney consists of two main parts: localization of renal cortex and segmentation of kidney components. In the(More)
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