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Signal transducer and activator of transcription (Stat) 3 is an oncogene constitutively activated in many cancer systems where it contributes to carcinogenesis. To develop chemical probes that selectively target Stat3, we virtually screened 920,000 small drug-like compounds by docking each into the peptide-binding pocket of the Stat3 SH2 domain, which(More)
Acute myeloid leukemia (AML) is the most common malignant myeloid disorder of progenitor cells in myeloid hematopoiesis and exemplifies a genetically heterogeneous disease. The patients with AML also show a heterogeneous response to therapy. Although all-trans retinoic acid (ATRA) has been successfully introduced to treat acute promyelocytic leukemia (APL),(More)
We extend the group decoding algorithm [1] for space time block code (STBC) to the non-binary low density parity check code (LDPC) with Quasi-Orthogonal STBC in multiple-input and multiple-output (MIMO) system. A Gaussian based detection is proposed to reduce the decoding complexity in this paper. The complexity involved grows linearly with the number of(More)
In this paper, a fully automatic method is proposed to segment the kidney into multiple components: renal cortex, renal column, renal medulla and renal pelvis, in clinical 3D CT abdominal images. The proposed fast automatic segmentation method of kidney consists of two main parts: localization of renal cortex and segmentation of kidney components. In the(More)
Association rules can mine the relevant evidence of computer crime from the massive data and association rules among data itemset, and further mine crime trends and connections among different crimes. They can help polices detect case and prevent crime with clues and criterions. Frequent itemset mining (FIM) plays a fundamental role in mining associations,(More)
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