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Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation.
TLDR
Results suggest that SchA exhibits anti-inflammatory effects against IL-1β-stimulated chondrocytes by blocking NF-κB and MAPKs signaling pathways. Expand
Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression
TLDR
It is demonstrated that pseudogene CTNNAP1, for the CTNNA1 gene, was dysregulated in colorectal cancer and the degree of dysregulation was remarkably associated with tumor node metastasis (TNM) stage (P<0.05). Expand
Duodenal-jejunal bypass for the treatment of type 2 diabetes in Chinese patients with an average body mass index<24 kg/m2.
TLDR
DJB can improve glycemic control in nonobese T2DM patients without significant weight loss but may not be effective enough to induce remission of T2 DM in non obese Chinese patients. Expand
Berberine modulates cisplatin sensitivity of human gastric cancer cells by upregulation of miR-203
TLDR
BER treatment reduces cisplatin resistance of gastric cancer cells by modulating the miR-203/Bcl-w apoptotic axis, and it is concluded that BER may be a novel agent to enhance chemotherapeutic responses in cisPlatin-resistant Gastric cancer patients. Expand
Pitavastatin suppressed liver cancer cells in vitro and in vivo
TLDR
The antiliver cancer effect of the old drug pitavastatin may be developed as a drug for liver cancer therapy and reversed the cleavage of cytotoxic effect of pitvastatin. Expand
Sphingosine kinase 1: A novel independent prognosis biomarker in hepatocellular carcinoma
TLDR
Evidence is provided that Sphk1 promotes HCC cell proliferation and is involved in tumor progression and the data presented suggest that SphK1 may be a potential independent prognosis biomarker for the treatment of HCC. Expand
Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer
TLDR
D6 may be a promising therapeutic agent for PC treatment and it provides a structural lead for the design of novel IKKβ inhibitors, as well as effectively inducing cancer cell apoptosis. Expand
Design , synthesis , and biological evaluation of novel EF 24 and EF 31 analogs as potential i κ B kinase β inhibitors for the treatment of pancreatic cancer
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