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LncRNA HOTTIP facilitates the stemness of breast cancer via regulation of miR‐148a‐3p/WNT1 pathway
TLDR
This study is the first to report that HOTTIP regulates the CSC‐like properties of BCSCs by as a molecular sponge for miR‐148a‐3p to increase WNT1 expression, offering a new target for breast cancer therapy. Expand
Hypoxia-mediated cancer stem cell resistance and targeted therapy.
TLDR
The feasibility and development prospects of using hypoxia-inducible factors that regulate the hypoxic microenvironment of tumors as targeted agents to treat tumors, as well as to reduce or even reverse the resistance of tumors to chemotherapy and radiotherapy. Expand
SNORD89 promotes stemness phenotype of ovarian cancer cells by regulating Notch1-c-Myc pathway
TLDR
SNORD89 deteriorates the prognosis of ovarian cancer patients by regulating Notch1-c-Myc pathway to promote cell stemness and acts as an oncogene in ovarian tumorigenesis and can be a novel prognostic biomarker and therapeutic target for ovarian cancer. Expand
lncRNA-Xist/miR-101-3p/KLF6/C/EBPα axis promotes TAM polarization to regulate cancer cell proliferation and migration
TLDR
It is indicated that Xist could mediate macrophage polarization to affect cell proliferation and migration of breast and ovarian cancer by competing with miR-101 to regulate C/EBPα and KLF6 expression. Expand
Identification of a panel of mitotic spindle‐related genes as a signature predicting survival in lung adenocarcinoma
TLDR
A mitotic spindle‐related signature is identified which could be an independent prognostic indicator, to predict the prognosis of patients with LUAD, and should offer opportunities to explore the pathogenesis of LUAD and prove clinically useful in predicting LUAD patient prognosis. Expand
SNORA72 Activates the Notch1/c-Myc Pathway to Promote Stemness Transformation of Ovarian Cancer Cells
TLDR
Stemness transformation of ovarian cancer cells can be activated by SNORA72 through the Notch1/c-Myc pathway, which is a novel therapeutic strategy for improving the treatment efficiency of Ovarian cancer. Expand
Identification of potential key genes and pathways predicting pathogenesis and prognosis for triple-negative breast cancer
TLDR
The eight hub genes associated with the cell cycle pathway highly expressed in TNBC might be tightly correlated with TNBC pathogenesis and act as an independent biomarker with a potentially good performance in predicting overall survival. Expand
Expression signature of six‐snoRNA serves as novel non‐invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma
TLDR
A six‐snoRNA signature is established as an independent and superior diagnosis and prognosis indicator for ccRCC and the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis inccRCC. Expand
Development of a novel gene signature in patients without Helicobacter pylori infection gastric cancer
TLDR
The seven‐mRNA signature was identified to act as an independent prognostic biomarker by stratified analysis and multivariate Cox regression analysis and it was validated on two test groups from TCGA and GSE15460 and shown that patients with high‐risk scores based on the expression of the seven mRNAs had significantly shorter survival times compared to patients with low‐ risk scores. Expand
Identification of Prognostic Alternative Splicing Signature in Triple-negative breast cancer
TLDR
A reliable and powerful TNBC prognostic signature is established and a splicing network that could be its underlying mechanism was discovered, which indicates a clear trend in the role of SF in TNBC. Expand
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