Xuelian Deng

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BACKGROUND Xenogeneic islet transplantation is an emerging therapeutic option for diabetic patients. However, immunological tolerance to xenogeneic islets remains a challenge. METHODS The current study used a pig-to-mouse discordant xenogeneic islet transplant model to examine antidonor xenogeneic immune responses during early and late rejection and to(More)
Dimensionality reduction has been attracted extensive attention in machine learning. It usually includes two types: feature selection and subspace learning. Previously, many researchers have demonstrated that the dimensionality reduction is meaningful for real applications. Unfortunately, a large mass of these works utilize the feature selection and(More)
Congenital dysfibrinogenemia (CD) is a qualitative fibrinogen disorder caused by an abnormal fibrinogen molecule structure, leading to dysfunctional blood coagulation. This study describes 3 cases of dysfibrinogenemia identified in the unrelated Chinese pedigrees.Routine coagulation screening tests were performed on the probands and their families. The(More)
Objective: We present a case of pheochromocytoma with fatal paroxysmal dyspnea hemoptysis and shock. A systematic review of literature on pheochromocytoma was performed to improve the understanding of the clinical manifestation, diagnosis and treatment of a typical pheochromocytoma. Methods: The clinical manifestation, diagnostic examination, operation mode(More)
OBJECTIVE To explore the clinical phenotype of a family affected with congenital dysfibrinogenemia and potential mutations underlying the disease. METHODS Coagulation testing and hepatorenal function testing were conducted on 18 individuals from three generations. Plasma fibrinogen was extracted and analyzed with SDS-PAGE electrophoresis. All of the exons(More)
Dysfibrinogenemia is characterized by blood coagulation dysfunction induced by an abnormal molecular structure of fibrinogen. Here, we describe a new case. A 32-year-old female was suspected of having dysfibrinogenemia during routine laboratory screening, based on her decreased functional fibrinogen level, normal fibrinogen antigen level, and prolonged(More)
Objectives: We analyzed gene mutations in a Chinese family with hereditary spherocytosis (HS) combined with glucose-6-phosphate dehydrogenase (G6PD) deficiency, and evaluated differences in clinical features and diagnose the comorbidities. Methods: G6PD mutations were identified using PCR with fluorescence melting curve analysis. Erythrocyte(More)
BACKGROUND In this study, the significance of fibrinogen concentration assessed by a combination of Clauss and prothrombin time (PT)-derived methods for screening for congenital dysfibrinogenemia were investigated, and the screening efficiency of fibrinogen PT-derived/Clauss ratio on congenital dysfibrinogenemia was analyzed. METHODS We compared(More)
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