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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
This study not only advances the understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.
Genomewide association study of leprosy.
- Fu-Ren Zhang, Wei Huang, Jian-jun Liu
- Biology, MedicineThe New England journal of medicine
- 31 December 2009
Variants of genes in the NOD2-mediated signaling pathway (which regulates the innate immune response) are associated with susceptibility to infection with M. leprae.
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
This is the first large genome-wide association study in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design and identified a new susceptibility locus within the LCE gene cluster on 1q21.
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma
To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, a genome-wide association study in 2,514 chronic HBV carriers followed by a 2-stage validation among 6 independent populations of chronicHBV carriers showed that HCC risk was significantly associated with two independent loci.
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2
It is found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain and may lead to new insights into the pathogenesis of schizophrenia.
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
This study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations, and suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
Profile of Childhood Vitiligo in China: An Analysis of 541 Patients
Of the 541 children with vitiligo, 60 (11.1%) had a family history, and 3 (0.6%) had more than one family member who was affected, and forty‐one children had an associated autoimmune disease: halo nevi and alopecia areata, which were observed in 39 (7.2%) and 2 ( 0.4%) children.
Genome-wide analyses of non-syndromic cleft lip with palate identify 14 novel loci and genetic heterogeneity
This study substantially increases the number of genetic susceptibility loci for NSCLP and provides important insights into the genetic aetiology of this common craniofacial malformation.
Multiple Loci within the Major Histocompatibility Complex Confer Risk of Psoriasis
It is demonstrated that there are at least two additional loci within the MHC conferring risk of psoriasis within the human leukocyte antigen (HLA) region, independently of HLA-Cw*0602 and the C6orf10 locus, suggesting the potential pathogenic involvement of Hla-B.