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Signal transducer and activator of transcription (Stat) 3 is an oncogene constitutively activated in many cancer systems where it contributes to carcinogenesis. To develop chemical probes that selectively target Stat3, we virtually screened 920,000 small drug-like compounds by docking each into the peptide-binding pocket of the Stat3 SH2 domain, which(More)
In this paper, we propose two variants of the additive Schwarz method for the approximation of second order elliptic boundary value problems with discon-tinuous coefficients, on nonmatching grids using the lowest order Crouzeix-Raviart element for the discretization in each subdomain. The overall discretization is based on the mortar technique for coupling(More)
A new approximate mortar condition is proposed for the lowest order Crouzeix-Raviart finite element on nonmatching grids, which uses only the nodal values on the interface for the calculation of the mortar projection. This approach allows for improved and more flexible algorithms compared to those for the standard mortar condition where nodal values in the(More)
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies have analyzed Treg frequency in the peripheral blood mononuclear cells (PBMCs) of pancreatic ductal adenocarcinoma (PDA) patients using flow cytometry (FCM), few studies have examined how intratumoral Tregs might contribute to immunosuppression in the tumor(More)