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Signal transducer and activator of transcription (Stat) 3 is an oncogene constitutively activated in many cancer systems where it contributes to carcinogenesis. To develop chemical probes that selectively target Stat3, we virtually screened 920,000 small drug-like compounds by docking each into the peptide-binding pocket of the Stat3 SH2 domain, which(More)
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies have analyzed Treg frequency in the peripheral blood mononuclear cells (PBMCs) of pancreatic ductal adenocarcinoma (PDA) patients using flow cytometry (FCM), few studies have examined how intratumoral Tregs might contribute to immunosuppression in the tumor(More)
AIM to investigate the effects of ATPM-ET [(-)-3-N-Ethylaminothiazolo [5,4-b]-N-cyclopropylmethylmorphinan hydrochloride] on physical dependence and behavioral sensitization to morphine in mice. METHODS the pharmacological profile of ATPM-ET was characterized using competitive binding and GTPγS binding assays. We then examined the antinociceptive effects(More)
The opioid receptors are a member of G protein-coupled receptors that mediate physiological effects of endogenous opioid peptides and structurally distinct opioid alkaloids. Although it is well characterized that there is differential receptor desensitization and internalization properties following activation by distinct agonists, the underlying mechanisms(More)
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In this paper, we propose two variants of the additive Schwarz method for the approximation of second order elliptic boundary value problems with discon-tinuous coefficients, on nonmatching grids using the lowest order Crouzeix-Raviart element for the discretization in each subdomain. The overall discretization is based on the mortar technique for coupling(More)
In this paper, some effective cascadic multigrid methods are proposed for solving the large scale symmetric or nonsymmetric algebraic systems arising from the finite volume methods for second order elliptic problems. It is shown that these algorithms are optimal in both accuracy and computational complexity. Numerical experiments are reported to support our(More)