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HCV core protein interacts with Dicer to antagonize RNA silencing.
RNA silencing is a form of nucleic acid-based immunity against viruses in plants and invertebrate animals. Successful viral infection requires evasion or suppression of gene silencing. Here, weExpand
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The REDUCED LEAFLET Genes Encode Key Components of the trans-Acting Small Interfering RNA Pathway and Regulate Compound Leaf and Flower Development in Lotus japonicus1[W][OA]
The endogenous trans-acting small interfering RNA (ta-siRNA) pathway plays a conserved role in adaxial-abaxial patterning of lateral organs in simple-leafed plant species. However, its function inExpand
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Enhancement of Canonical Wnt/β-Catenin Signaling Activity by HCV Core Protein Promotes Cell Growth of Hepatocellular Carcinoma Cells
Background The Hepatitis C virus (HCV) core protein has been implicated as a potential oncogene or a cofactor in HCV-related hepatocellular carcinoma (HCC), but the underlying mechanisms are unknown.Expand
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Hepatitis B virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells.
The hepatitis B virus (HBV) protein plays a major role in hepatocellular carcinoma (HCC) development. However, its contribution to tumor invasion and metastasis has not been established so far. HLJ1Expand
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APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription
ABSTRACT Hepatitis B virus is a partially double‐stranded DNA virus that replicates by reverse transcription, which occurs within viral core particles in the cytoplasm. The cytidine deaminaseExpand
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HBx mutations promote hepatoma cell migration through the Wnt/β‐catenin signaling pathway
HBx mutations (T1753V, A1762T, G1764A, and T1768A) are frequently observed in hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC). Aberrant activation of the Wnt/β‐catenin signalingExpand
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Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway
  • X. Chen, Y. Hu, +9 authors N. Tang
  • Chemistry, Medicine
  • Free radical biology & medicine
  • 1 February 2019
ABSTRACT Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV‐infectedExpand
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Structural Basis of the Novel S. pneumoniae Virulence Factor, GHIP, a Glycosyl Hydrolase 25 Participating in Host-Cell Invasion
Pathogenic bacteria produce a wide variety of virulence factors that are considered to be potential antibiotic targets. In this study, we report the crystal structure of a novel S. pneumoniaeExpand
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The Crystal Structure of Hexamer RraA from Pseudomonas Aeruginosa Reveals Six Conserved Protein–Protein Interaction Sites
RNase E functions as the rate-limiting enzyme in the global mRNA metabolism as well as in the maturation of functional RNAs. The endoribonuclease, binding to the PNPase trimer, the RhlB monomer, andExpand
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Crystal structure of a novel dimer form of FlgD from P. aeruginosa PAO1
Crystal structure of a novel dimer form of FlgD from P. aeruginosa PAO1 Hua Zhou,1,2y Miao Luo,1,2y Xuefei Cai, Jian Tang, Siqiang Niu, Wenlu Zhang, Yuan Hu, Yibing Yin, Ailong Huang, Dacheng Wang,Expand
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