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The class imbalance problem is encountered in a large number of practical applications of machine learning and data mining, for example, information retrieval and filtering, and the detection of credit card fraud. It has been widely realized that this imbalance raises issues that are either nonexistent or less severe compared to balanced class cases and(More)
The class imbalance problem is encountered in real-world applications of machine learning and results in a classifier's suboptimal performance. Researchers have rigorously studied the resampling, algorithms, and feature selection approaches to this problem. No systematic studies have been conducted to understand how well these methods combat the class(More)
MOTIVATION Protein interactions are of biological interest because they orchestrate a number of cellular processes such as metabolic pathways and immunological recognition. Domains are the building blocks of proteins; therefore, proteins are assumed to interact as a result of their interacting domains. Many domain-based models for protein interaction(More)
While genome sequencing projects have generated tremendous amounts of protein sequence data for a vast number of genomes, substantial portions of most genomes are still unannotated. Despite the success of experimental methods for identifying protein functions, they are often lab intensive and time consuming. Thus, it is only practical to use in silico(More)
BACKGROUND Detecting epistatic interactions associated with complex and common diseases can help to improve prevention, diagnosis and treatment of these diseases. With the development of genome-wide association studies (GWAS), designing powerful and robust computational method for identifying epistatic interactions associated with common diseases becomes a(More)
Deep belief nets (DBNs) with restricted Boltzmann machines (RBMs) as the building block have recently attracted wide attention due to their great performance in various applications. The learning of a DBN starts with pretraining a series of the RBMs followed by fine-tuning the whole net using backpropagation. Generally, the sequential implementation of both(More)