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The class imbalance problem is encountered in a large number of practical applications of machine learning and data mining, for example, information retrieval and filtering, and the detection of credit card fraud. It has been widely realized that this imbalance raises issues that are either nonexistent or less severe compared to balanced class cases and(More)
MOTIVATION Protein interactions are of biological interest because they orchestrate a number of cellular processes such as metabolic pathways and immunological recognition. Domains are the building blocks of proteins; therefore, proteins are assumed to interact as a result of their interacting domains. Many domain-based models for protein interaction(More)
BACKGROUND Detecting epistatic interactions associated with complex and common diseases can help to improve prevention, diagnosis and treatment of these diseases. With the development of genome-wide association studies (GWAS), designing powerful and robust computational method for identifying epistatic interactions associated with common diseases becomes a(More)
OBJECTIVE Adverse drug reaction (ADR) is one of the major causes of failure in drug development. Severe ADRs that go undetected until the post-marketing phase of a drug often lead to patient morbidity. Accurate prediction of potential ADRs is required in the entire life cycle of a drug, including early stages of drug design, different phases of clinical(More)
In many practical applications, learning from imbalanced data poses a significant challenge that is increasingly faced by the machine learning community. The class imbalance problem raises issues that are either nonexistent or less severe compared to balanced class cases. This paper presents a new method for imbalanced data classification. The proposed(More)