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Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute
  • Nan Zhou, T. Pan, +9 authors Hui Zhang
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 7 March 2016
TLDR
This work identified that teicoplanin, a glycopeptide antibiotic, potently prevents the entry of Ebola envelope pseudotyped viruses into the cytoplasm via high throughput screening of Food and Drug Administration-approved drugs. Expand
NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
TLDR
This study demonstrates for the first time that NO-mediated redox regulation is the mechanism of PTEN protein degradation, which is distinguished from the H2O2-mediated PTEN oxidation, known to only inactivate the enzyme. Expand
Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation
TLDR
A novel neuroprotective function for APP is defined in preventing tau hyperphosphorylation via suppressing overactivation of CDK5, which is suggested to play a key role in neuronal excitotoxicity and represents an underlying mechanism for the physiological functions of APP. Expand
APOBEC3G Inhibits MicroRNA-mediated Repression of Translation by Interfering with the Interaction between Argonaute-2 and MOV10*
TLDR
It is demonstrated that A3G counteracts miRNA-mediated repression of translation by inhibiting the interaction between moloney leukemia virus 10 (MOV10) protein and Argonaute-2 (AGO2), causing either abnormal assembly or abnormal maturation of mi RNA-inducing silencing complex (miRISC). Expand
Transcriptional regulation of APH‐1A and increased γ‐secretase cleavage of APP and Notch by HIF‐1 and hypoxia
TLDR
The results demonstrate that APH‐1A expression and the γ‐secretase mediated Aβ and Notch NICD generation are regulated by HIF‐1, and the specific control of APH •1Aexpression may imply physiological functions uniquely assigned to APH•1A. Expand
Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs.
TLDR
It is demonstrated that let-7i sequence specifically binds to the TATA-box motif of interleukin-2 (IL-2) gene and elevates IL-2 mRNA and protein production in CD4(+) T-lymphocytes in vitro and in vivo. Expand
A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes
TLDR
A novel piRNA mechanism in regulating gene expression in highly differentiated somatic cells and a possible novel target for allergy therapeutics are demonstrated. Expand
Identification of an HIV-1 replication inhibitor which rescues host restriction factor APOBEC3G in Vif-APOBEC3G complex.
TLDR
A potent HIV-1 replication inhibitor (ZBMA-1, IC50 = 1.01 μM) is identified that efficiently protected APOBEC3G protein by targeting Vif-APOBec3G complex and affected the binding of Elongin C with Vif protein. Expand
Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair*
TLDR
It is shown that stabilization of UVSSA by interaction with USP7 is essential for TC-NER, a subpathway of nucleotide excision repair that rapidly removes transcription-blocking DNA damage. Expand
Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation
TLDR
The results support the notion that optimal substrate degradation by IDE may require its association with organized-DRMs, and the concept that mis-location of Aβ degrading proteases away from DRMs may impair the physiological turn-over of A β in vivo deserves further investigation. Expand
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