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The tumor microenvironment is replete with proteinases. As a sensor of proteinases, proteinase activated receptor 2 (PAR2) plays critical roles in tumorigenesis. We showed that PAR2 and its activating proteinase were coexpressed in different colon cancer cell lines, including HT29. Inactivating proteinase or knockdown of PAR2 significantly not only reduced(More)
DNA polymerase η (Polη) implements translesion DNA synthesis but has low fidelity in replication. We have previously shown that Polη plays an important role in the genesis of nontargeted mutations at undamaged DNA sites in cells exposed to the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Here, we report that MNNG-induced Polη expression in an(More)
This study investigated the subtype distribution of the human papillomavirus (HPV) in the patients with condyloma accuminatum (CA) in Shenzhen city, China, and assessed the relationship between different HPV subtypes and cervical neoplasia. Type-specific prevalence and extent of multiple infections were assessed in the genital tract. CA samples collected(More)
The Mongolian Plateau (MP), which is situated in the interior of Asia and possesses a typical continental climate, experienced harsh climatic conditions during the Quaternary glacial fluctuations. Although these events likely had huge impacts on the local animal populations, the current effects have hardly been explored. To investigate whether the MP(More)
This paper describes one of the critical technologies of very high speed integrated circuits (VHSICs), the equivalent circuit model of the GaAs substrate based coupled microstrip lines. We present a method that extracts a frequency-dependent tabular RLGC model from mixed-mode S-parameters estimated by EM simulation (software HFSS). This paper shows that the(More)
PURPOSE This study summarizes the literature concerning osteochondroma of the mandibular coronoid process and presents a case of 1-stage treatment for this condition and concomitant facial asymmetry. MATERIALS AND METHODS A 20-year-old man presented with osteochondroma of the mandibular coronoid process. Radiologic images showed a mushroom-shaped coronoid(More)
Climatic niche conservatism shapes patterns of diversity in many taxonomic groups, while ecological opportunity (EO) can trigger rapid speciation that is less constrained by the amount of time a lineage has occupied a given habitat. These two processes are well studied, but limited research has considered their joint and relative roles in shaping diversity(More)
Inland East Asia encompasses particular landscapes, including discontinuous large deserts isolated by mountains, and these landscapes have been greatly impacted by the uplift of the Qinghai-Tibetan Plateau (QTP) since the Pliocene. However, little research has been performed on the impact of desertification on the evolutionary history of animals in this(More)
Aiming at such problems as decentralized management, difficult querying and modification, poor information sharing, etc. Of the current Information Security Emergency Plan Management (ISEPM), ASP.NET MVC design mode has been applied for designing and developing the Web-based ISEPM in realizing formulation, auditing and publicity for plans via workflow.
This study aimed to determine whether enamel matrix derivative (Emdogain) affects the demineralization of bovine enamel in vitro and to assess the agent's anti-caries potential. Bovine enamel blocks were prepared and randomly divided into three groups (n = 15 per group), which were treated with distilled water (negative control), NaF (positive control), or(More)