Xue-Nan Sun

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Although antagonists of mineralocorticoid receptor (MR) have been widely used to treat heart failure, the underlying mechanisms are incompletely understood. Recent reports show that T cells play important roles in pathologic cardiac hypertrophy and heart failure. However, it is unclear whether and how MR functions in T cells under these pathologic(More)
Mineralocorticoid receptor (MR) has been considered as a potential target for treating atherosclerosis. However, the cellular and molecular mechanisms are not completely understood. We aim to explore the functions and mechanisms of macrophage MR in atherosclerosis. Atherosclerosis-susceptible LDLRKO chimeric mice with bone marrow cells from floxed control(More)
A reconstruction algorithm of a function on a circular domain which was given by Marr is analyzed deeply. The problem found by us with this approach is that the term r/sup n/Q/sub n,k/ (r/sup 2/)included in the Marr's expansion algorithm has local large oscillation if n and k are very large. From that, numerical difficulties may arise and image distortion(More)
RATIONALE Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells and T-cell-derived cytokines. Mineralocorticoid receptor (MR) antagonists have been clinically used to treat hypertension. However, the function of T-cell MR in blood pressure (BP) regulation has not been elucidated. (More)
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