Xue-Nan Sun

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RATIONALE Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells and T-cell-derived cytokines. Mineralocorticoid receptor (MR) antagonists have been clinically used to treat hypertension. However, the function of T-cell MR in blood pressure (BP) regulation has not been elucidated. (More)
A reconstruction algorithm of a function on a circular domain which was given by Marr is analyzed deeply. The problem found by us with this approach is that the term r/sup n/Q/sub n,k/ (r/sup 2/)included in the Marr's expansion algorithm has local large oscillation if n and k are very large. From that, numerical difficulties may arise and image distortion(More)
Mineralocorticoid receptor (MR) has been considered as a potential target for treating atherosclerosis. However, the cellular and molecular mechanisms are not completely understood. We aim to explore the functions and mechanisms of macrophage MR in atherosclerosis. Atherosclerosis-susceptible LDLRKO chimeric mice with bone marrow cells from floxed control(More)
Although antagonists of mineralocorticoid receptor (MR) have been widely used to treat heart failure, the underlying mechanisms are incompletely understood. Recent reports show that T cells play important roles in pathologic cardiac hypertrophy and heart failure. However, it is unclear whether and how MR functions in T cells under these pathologic(More)
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