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  • Scott Sherwood Benson, Nils J Nilsson, Yoav Shoham, Barbara Hayes-Roth, Marko Balabanovic, Lise Getoor +24 others
  • 1996
ii I certify that I have read this dissertation and that in my opinion it is fully adequate, in scope and quality, a s a dissertation for the degree of Doctor of Philosophy. I certify that I have read this dissertation and that in my opinion it is fully adequate, in scope and quality, a s a dissertation for the degree of Doctor of Philosophy. I certify that(More)
Epilepsy is heritable, yet few causative gene mutations have been identified, and thus far no human epilepsy gene mutations have been found to produce seizures in invertebrates. Here we show that mutations in prickle genes are associated with seizures in humans, mice, and flies. We identified human epilepsy patients with heterozygous mutations in either(More)
Microtubule-associated protein 1A (MAP1A) and MAP1B are developmentally regulated proteins linked to axon formation. They each consist of a unique heavy chain and three common light chains. We used immunofluorescence microscopy to qualitatively assess the variability in MAP1 subunit expression between individual cells. The ratio of light chain 1 to MAP1(More)
The MAP1B and MAP1A genes each produce an mRNA that encodes a polyprotein. When cleaved, each polyprotein yields a single heavy chain and a single light chain, which become noncovalently associated. In previous work, it was found that the MAP1B light chains and heavy chains exist in a 2:1 ratio. Through use of quantitative immunoblot techniques, this(More)
Scenes with cast shadows can produce complex sets of images. These images cannot be well approximated by low-dimensional linear subspaces. However, in this paper we show that the set of images produced by a Lambertian scene with cast shadows can be efficiently represented by a sparse set of images generated by directional light sources. We first model an(More)
We present a computationally inexpensive method for multi-modal image registration. Our approach employs a joint gradient similarity function that is applied only to a set high spatial gradient pixels. We obtain motion parameters by maximizing the similarity function by gradient ascent method, which secures a fast convergence. We apply our technique to the(More)
Previous studies indicated that EAF (ELL-associated factor) family members, EAF1 and EAF2/U19, play a role in cancer and embryogenesis. For example, EAF2/U19 may serve as a tumor suppressor in prostate cancer. At the same time, EAF2/U19 is a downstream factor in the non-canonical Wnt 4 signaling pathway required for eye development in Xenopus laevis, and(More)
The effects produced in an image by cast shadows can be quite complex, especially when light comes from all directions. This makes it difficult to recover the illumination from a scene and recognize objects from the images. In this paper, we show that such images can be well approximated using much simpler lighting represented by a combination of low(More)
To learn the matching function that operates on pairs of data, we use a Siamese architecture with two branches [1, 2]. The Siamese network processes the two inputs separately through individual networks that take the form of a convolutional neural network. For individual branches, we investigate two different network architectures, a small one adapted from(More)
Recommended Citation Mei, Xue. "Wnt/planar cell polarity mechanisms in epilepsy and interactions with ciliopathy." PhD (Doctor of Philosophy) thesis, ii ACKNOWLEDGMENTS First, I would like to thank my Ph.D advisor Dr. Diane C. Slusarski. Diane has provided a nurturing research environment and excellent support for me to conduct research. She makes herself(More)