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The objective of this study was to develop a suitable formulation for baicalein (a poorly water-soluble drug exhibiting high melting point) to prepare solid dispersions using hot melt extrusion (HME). Proper carriers and plasticizers were selected by calculating the Hansen solubility parameters, evaluating melting processing condition, and measuring the(More)
Previous studies demonstrated that the rewarding effect of psychostimulants, such as amphetamine and cocaine, can be predicted by locomotor activity toward novelty in a free-choice situation but not motor response developed in inescapable environment. However, whether this relationship also exists with narcotic morphine remains unclear. In the present(More)
BACKGROUND Clinical needs often dictate testing for several autoantibodies in a single patient with evidence of autoimmune disease. We developed a microarray containing 15 autoantigens for the detection of autoantibodies in rheumatoid autoimmune diseases. METHODS We synthesized recombinant centromere protein B, cytokeratin 19, SSA 52-kDa antigen, SSA(More)
Novel breast carcinoma dual-targeted redox-responsive nanoparticles (NPs) based on cholesteryl-hyaluronic acid conjugates were designed for intracellular delivery of the antitumor drug doxorubicin (DOX). A series of reduction-responsive hyaluronic acid derivatives grafted with hydrophobic cholesteryl moiety (HA-ss-Chol) and GE11 peptide conjugated(More)
The potential harmful effects of media violence have been studied systematically and extensively. However, very little attention has been devoted to the intrigue and struggles between people depicted in the mass media. A longitudinal randomized experimental group-control group, pretest-posttest design study was conducted to examine the potential effects of(More)
The Parent Form of the Social Competence Scale (SCS-PF) was translated into Chinese and validated in a sample of Chinese preschool children (N = 443). Results confirmed a single dimension and high internal consistency in the SCS-PF. Mothers' ratings on the SCS-PF correlated moderately with teachers' ratings on the Teacher Form of the Social Competence Scale(More)
In a sample of 2- and 3-yr.-old Chinese children (N = 156), mothers' and teachers' ratings showed modest correspondence on boys' internalizing psychopathology but no correspondence on girls' internalizing. Mothers' and teachers' ratings also showed no correspondence on externalizing psychopathology across child's gender. Mothers' ratings were found to be(More)
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