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Hepatocellular carcinoma (HCC) is a highly malignant tumor, and chronic infection with hepatitis B virus is one of its major risk factors. To identify the proteins involved in HCC carcinogenesis, we used two-dimensional fluorescence DIGE to study the differentially expressed proteins in tumor and adjacent nontumor tissue samples. Samples from 12 hepatitis B(More)
BACKGROUND We hypothesized that atherosclerosis inhibits NO-mediated endothelium-dependent dilation of coronary arterioles through interaction of ox-LDL with its receptor, LOX-1, through the production of O2ÿ- in endothelial cells. METHODS AND RESULTS We assessed the role of ox-LDL in endothelial dysfunction in a murine model of atherosclerosis (ApoE KO(More)
FTO (fat mass and obesity associated) was identified as an obesity-susceptibility gene by several independent large-scale genome association studies. A cluster of SNPs (single nucleotide polymorphism) located in the first intron of FTO was found to be significantly associated with obesity-related traits, such as body mass index, hip circumference, and body(More)
AIM Cardiac microvascular endothelial cells (CMECs) dysfunction contributes to cardiovascular complications in diabetes, whereas, the underlying mechanism is not fully clarified. FoxO transcription factors are involved in apoptosis and reactive oxygen species (ROS) production. Therefore, the present study was designed to elucidate the potential role of(More)
AIM To explore the role of the glucagon-like peptide 1 receptor (GLP-1R) in geniposide regulated insulin secretion in rat INS-1 insulinoma cells. METHODS Rat INS-1 insulinoma cells were cultured. The content of insulin in the culture medium was measured with ELISA assay. GLP-1R gene in INS-1 cells was knocked down with shRNA interference. The level of(More)
SIFT descriptor has been widely applied in computer vision and object recognition, but has not been explored in the field of handwritten Chinese character recognition. In this paper we proposed a novel SIFT based feature for offline handwritten Chinese character recognition. The presented feature is a modification of SIFT descriptor taking into account of(More)
In this paper, an online handwritten Chinese character segmentation method is proposed. It is based on a dynamic programming algorithm, which uses geometrical features extracted from the handwritten strokes. The algorithm is carried out in two stages: pre-segmentation and recognition-based segmentation. The experimental results on 2363 sentences,(More)
Writer adaptive handwriting recognition, which has potential of increasing accuracies for a particular user, is the process of converting a writer-independent recognition system to a writer-dependent one. In this paper, we provide a general incremental learning solution for linear discriminant analysis (LDA) on the basis of previous researches, and propose(More)
The fruit flesh color of papaya is an important nutritional quality trait and is due to the accumulation of carotenoid. To elucidate the carotenoid biosynthesis pathway in Carica papaya, the phytoene desaturase (PDS) and the ζ-carotene desaturase (ZDS) genes were isolated from papaya (named CpPDS and CpZDS) using the rapid amplification of cDNA ends (RACE)(More)