The c-Jun N-terminal kinases (JNKs), serine/threonine protein kinases including three isoforms: JNK1, JNK2, and JNK3 are attractive targets for the treatment of neurodegenerative disorders. Many reported JNKs inhibitors could prevent neuronal degradation, but most exist with selective vulnerability to toxic effects. In this paper, we had applied a combined… (More)
In the title hydrate, C(4)H(7)N(3)O(2)·H(2)O, all the non-H atoms lie on a crystallographic mirror plane. The H atoms of both methyl groups are disordered over two sets of sites. In the crystal, N-H⋯O(w) and O(w)-H⋯O(k) (w = water and k = ketone) hydrogen bonds link the components into (010) sheets.
The title mol-ecule, C(10)H(8)ClN(3)O(7), is twisted with the dihedral angle between the amide and benzene ring being 38.75 (11)°. The C-N-C-C torsion angle between the amide and acetyl groups is -150.1 (2)°. Finally, each nitro group is twisted out of the plane of the benzene ring to which it is connected [O-N-C-C torsion angles = 34.0 (3) and -64.5 (3)°].… (More)
The title compound, C(14)H(21)Cl(3)O(9)·2H(2)O, is a disaccharide constructed from a galactose and a fructose. In the mol-ecular structure, the tetra-hydro-furan five-membered ring and tetra-hydro-pyran six-membered ring assume envelope and chair conformations, respectively. An extensive O-H⋯O hydrogen-bonding network occurs in the crystal structure.