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EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis
TLDR
Although increased EGFR GCN is generally associated with a better outcome ofAnti-EGFR MAbs treatment, especially among patients with wild-type KRAS, the clinical utility of this biomarker for selecting recipients of anti-EGfr MAbs would be severely limited by the heterogeneous scoring system and the poor reproducibility of EG FR GCN enumeration due to technical reasons.
Chemotherapy with cetuximab versus chemotherapy alone for chemotherapy-naive advanced non-small cell lung cancer.
TLDR
To evaluate the efficacy and toxicity of chemotherapy plus cetuximab, compared with chemotherapy alone, for advanced non-small cell lung cancer (NSCLC) previously untreated with chemotherapy or epidermal growth factor receptor (EGFR)-targeted drugs, four trials are included.
Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer.
TLDR
The results of the present study demonstrated the oncogenic role of HOXA11‑AS in breast cancer, providing novel clues for the future clinical diagnosis and treatment of early stage breast cancer patients.
Prognostic value of total tumor volume in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy
TLDR
TTV is an important prognosticator for treatment outcome and significantly improves the prognostic value of the current staging system for patients with NPC treated with IMRT, as revealed by ROC curve analysis curves.
Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy?
TLDR
MPTD was an independent prognostic factor in patients with NPC treated using IMRT, and significantly improved the prognostic value of the current T classification criteria for NPC.
Prognostic Value of Classifying Parapharyngeal Extension in Nasopharyngeal Carcinoma Based on Magnetic Resonance Imaging
TLDR
Parapharyngeal extension in NPC should be subclassified as mild or extensive, which should be regarded as stages T2 and T4 diseases, respectively.
Interleukin-2 as maintenance therapy for children and adults with acute myeloid leukaemia in first complete remission.
TLDR
The efficacy and safety of IL-2 as maintenance therapy for children and adults with AML who have achieved first CR and have not relapsed is evaluated and inverse-variance method was used to combine HRs with fixed-effect model unless there was significant between-study heterogeneity.
Survival and Toxicities of IMRT Based on the RTOG Protocols in Patients with Nasopharyngeal Carcinoma from the Endemic Regions of China
TLDR
The RTOG IMRT protocols are feasible for patients with NPC from the endemic regions of China, and T and N category were significant prognostic factors for OS, FFS, RRFS and DMFS.
Study of MR image for involvement of paranasal sinuses in 56 cases with nasopharyngeal carcinoma
TLDR
The findings of sinuses wall breakage, thick mucous membrane in sinuses, tumour invasion cavity connective mass, and same enhancement signal in MR image may indicate the paranasal sinuses involved by primary tumour.
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