Xudong Shang

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Rapid cellular uptake and efficient drug release in tumor cells are two of the major challenges for cancer therapy. Herein, we designed and synthesized a novel pH-responsive polymer-drug conjugate system poly(2-(methacryloyloxy)ethyl choline phosphate)-b-poly(2-methoxy-2-oxoethyl methacrylate-hydrazide-doxorubicin) (PCP-Dox) to overcome these two challenges(More)
Poly(3-hexylthiophene) (P3HT) has been widely used in devices owing to its excellent properties and structural features. However, devices based on pure P3HT have not exhibited high performance. Strategies, such as thermal annealing and surface doping, have been used to improve the electrical properties of P3HT. In this work, different from previous studies,(More)
Limited cellular uptake and inefficient intracellular drug release severely hamper the landscape of polymer drug nanocarriers in cancer chemotherapy. Herein, to address these urgent challenges in tumor treatment simultaneously, we integrated the multivalent choline phosphate (CP) and bioreducible linker into a single polymer chain, designed and synthesized(More)
Gene expression can be regulated through transcriptional and post-transcriptional mechanisms. Transcription in eukaryotes produces pre-mRNA molecules, which are processed and spliced post-transcriptionally to create translatable mRNAs. More than one mRNA may be produced from a single pre-mRNA by alternative splicing (AS); thus, AS serves to diversify an(More)
In this paper, we consider the existence and concentration behavior of positive ground state solution to the following problem { −hΔpu+V (x)|u|p−2u = K(x)|u|q−2u+ |u|p−2u, x ∈ RN , u ∈W 1,p(RN ), u > 0, x ∈ RN , where h is a small positive parameter, 1 < p < N , max{p, p∗ − p p−1} < q < p∗ , p∗ = Np N−p is the critical Sobolev exponent, V (x) and K(x) are(More)
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