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Nuclear termination of STAT3 signaling through SIPAR (STAT3‐Interacting Protein As a Repressor)‐dependent recruitment of T cell tyrosine phosphatase TC‐PTP
It is demonstrated that SIPAR directly interacts with T cell protein tyrosine phosphatase TC45 and enhances its association with STAT3 and triggers an accelerated dephosphorylation process for STAT3. Expand
CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer
This study provides a mechanism by which gastric tumor cells maintain their high proliferation rate via coordination of Aurora B and CREPT/RPRD1B on the expression of Cyclin B1. Expand
GdX/UBL4A‐knockout mice resist collagen‐induced arthritis by balancing the population of Th1/Th17 and regulatory T cells
It is reported that the small ubiquitin‐like protein X‐linked gene in the G6PD cluster at Xq28 (GdX) regulates the balance of Th17 and regulatory T (Treg) cells during collagen‐induced arthritis (CIA) mice, and the splenocytes of GdX‐knockout mice were insensitive to T‐cell stimulants. Expand
Dimerization of p15RS mediated by a leucine zipper–like motif is critical for its inhibitory role on Wnt signaling
  • Xuanzi Fan, Juan Zhao, +10 authors Z. Chang
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 4 April 2018
It is reported that dimerization of p15RS governed by the leucine zipper–like motif is critical for its inhibition of Wnt/β-catenin signaling and tumorigenesis. Expand