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Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility
Germinal centres support antibody affinity maturation and memory formation. Follicular T-helper cells promote proliferation and differentiation of antigen-specific B cells inside the follicle. A… Expand
The kappa-opioid receptor is upregulated in the spinal cord and locus ceruleus but downregulated in the dorsal root ganglia of morphine tolerant rats
As a non-selective agonist of opioid receptors, morphine can also act on the kappa-opioid receptor (KOR) when activating the mu-opioid receptor (MOR) and delta-opioid receptor (DOR). Although… Expand
FOXO1 deficiency impairs proteostasis in aged T cells
Impaired FOXO1 expression in CD4 T cell responses from old adults causes expanded multivesicular bodies sequestering GSK3β. T cell differentiation involves the dynamic regulation of FOXO1 expression,… Expand
[Effect of fentanyl on expression of mu-receptor and beta-arrestin 2 in periaqueductal gray of rats tolerant to morphine].
OBJECTIVE To investigate the effect of fentanyl upon the expression of mu-receptor and beta-arrestin 2 in peri-aqueductal gray of morphine-tolerant rats. METHODS Forty male SD rats weighing (230… Expand
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
- Wenqiang Cao, F. Fang, +6 authors J. Goronzy
- Biology, Medicine
- The Journal of clinical investigation
- 26 May 2020
Vaccination is a mainstay in preventive medicine, reducing morbidity and mortality from infection, largely by generating pathogen-specific neutralizing antibodies. However, standard immunization… Expand
Anterior herniation of lumbar disc induces persistent visceral pain: discogenic visceral pain
- Y. Tang, M. Shannon, Guang-Hui Lai, Xuan-ying Li, N. Li, Jia-xiang Ni
- Chinese medical journal
- 20 December 2013
Background Visceral pain is a common cause for seeking medical attention. Afferent fibers innervating viscera project to the central nervous system via sympathetic nerves. The lumbar sympathetic… Expand
Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells
Healthy immune aging is in part determined by how well the sizes of naïve T cell compartments are being maintained with advancing age. Throughout adult life, replenishment largely derives from… Expand