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FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity
TLDR
It is shown that recruitment of SRC to FRS2 leads to activation of signal attenuation pathways, and that hSpry2 is a direct substrate for SRC family kinases, including SRC itself. Expand
CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear‐resistant leukocyte rolling via l‐selectin
TLDR
CHST1 and CHST2 contribute to the generation of optimal l‐selectin ligands in vascular endothelial cells at sites of inflammation, and increased CHST1 orCHST2 expression by a cell line expressing low‐level l‐ selectin ligand activity during in vitro flow chamber assays increased rolling leukocyte numbers, reduced rolling velocities, and enhanced leukocytes rolling under higher shear stresses. Expand
The Selectins and their Ligands: Adhesion Molecules of the Vasculature
TLDR
The differential expression and function of the selectins by various leukocytes subclasses and diverse beds of vascular endothelium allows for considerable specificity in leukocyte migration into tissues at sites of inflammation, wound healing, and immune responses. Expand
AMPK: a balancer of the renin–angiotensin system
TLDR
This review serves to draw attention to the cross-talk between RAS and AMPK, then summering the most recent literature which highlights AMPK as a point of balance between physiological and pathological functions of the RAS. Expand
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson’s Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function
TLDR
FG-4592 is a promising therapeutic strategy for PD through improving the mitochondrial function under oxidative stress through up-regulating nuclear factor erythroid 2 p45-related factor 2 (Nrf-2), heme oxygenase-1 (HO-1) and superoxide dismutase 2 (SOD2). Expand
Mangiferin prevents diabetic nephropathy progression in streptozotocin‐induced diabetic rats
TLDR
Mangiferin could significantly prevent progression of diabetic nephropathy and improve renal function. Expand
Regulation of L-Selectin–mediated Rolling through Receptor Dimerization
TLDR
L-selectin dimerization significantly increased the number of lymphocytes rolling on vascular endothelium under a broad range of physiological shear stresses, and significantly slowed their rolling velocities, suggesting it may directly influence leukocyte migration to peripheral lymphoid tissues or to sites of inflammation. Expand
Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells.
TLDR
Hypoxia induces PAI-1 expression via remarkable nuclear accumulation of HIF-1alpha and partially via NF-kappaB activation in HPTECs through activation of plasminogen activator inhibitor-1 and TNF-alpha. Expand
Angiotensin II activates connective tissue growth factor and induces extracellular matrix changes involving Smad/activation and p38 mitogen‐activated protein kinase signalling pathways in human
TLDR
Results show that Ang II activation of Smad2 occurs via the AT1 receptor, but not the AT2 receptor, showing that Smad activation is involved in Ang II‐induced dermal fibrosis. Expand
1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice
TLDR
It is demonstrated that 1-Deoxynojirimycin can increase hepatic insulin sensitivity via strengthening of the insulin-stimulated PKB/GSK-3β signal pathway and by modulating glucose metabolic enzymes in db/db mice. Expand
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