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STUDY OBJECTIVES The state instability hypothesis posits that increasing sleep drive brings about escalating state instability in attention, making neurobehavioral performance increasingly variable. This hypothesis predicts that performance variability is a function of prior wake, circadian phase, and time on task. These predictions have been supported when(More)
BACKGROUND Substantial data indicate that the oncogene microRNA 21 (miR-21) is significantly elevated in glioblastoma multiforme (GBM) and regulates multiple genes associated with cancer cell proliferation, apoptosis, and invasiveness. Thus, miR-21 can theoretically become a target to enhance the chemotherapeutic effect in cancer therapy. So far, the effect(More)
Keyword queries over structured databases are notoriously ambiguous. No single interpretation of a keyword query can satisfy all users, and multiple interpretations may yield overlapping results. This paper proposes a scheme to balance the relevance and novelty of keyword search results over structured databases. Firstly, we present a probabilistic model(More)
STUDY OBJECTIVES The homeostatic-circadian regulation of neurobehavioral functioning is not well understood in that the role of sleep dose in relation to prior wake and circadian phase remains largely unexplored. The aim of the present study was to examine the neurobehavioral impact of sleep dose at different combinations of prior wake and circadian phase.(More)
AIMS MicroRNA-21 (miR-21) expression is increased in many types of human malignancy, including glioma. Recent studies report that miR-21 regulates cell invasion by targeting RECK, however, the underlying transcriptional regulation of miR-21 in glioma cells remains elusive. RESULTS Here, we identify a positive correlation between miR-21 expression and(More)
There is a trend that, virtually everyone, ranging from big Web companies to traditional enterprisers to physical science researchers to social scientists, is either already experiencing or anticipating unprecedented growth in the amount of data available in their world, as well as new opportunities and great untapped value. This paper reviews big data(More)
This study investigates the relationship between changing gasoline prices and drunk-driving crashes. Specifically, we examine the effects of gasoline prices on drunk-driving crashes in Mississippi by several crash types and demographic groups at the monthly level from 2004 to 2008, a period experiencing great fluctuation in gasoline prices. An exploratory(More)
DNA methylation plays a key role in the regulation of gene expression. The most common type of DNA modification consists of the methylation of cytosine in the CpG dinucleotide. The detections of DNA methylation have been determined mostly by experimental methods, which were time-consuming and expensive, difficult to meet the requirements of modern(More)