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In this paper, a Spectral Stochastic Collocation Method (SSCM) is proposed for the capacitance extraction of interconnects with stochastic geometric variations for nanometer process technology. The proposed SSCM has several advantages over the existing methods. Firstly, compared with the PFA (Principal Factor Analysis) modeling of geometric variations, the(More)
The recently-introduced susceptance element exhibits many prominent features in modeling the on-chip magnetic couplings. For an RCS circuit, it is better to be formulated as a second-order system. Therefore, corresponding MOR (model-order reduction) techniques for second-order systems are desired to efficiently deal with the ever-increasing circuit scale(More)
The recognition between disease resistance (R) genes in plants and their cognate avirulence (Avr) genes in pathogens can produce a hypersensitive response of localized programmed cell death. However, our knowledge of the early signaling events of the R gene-mediated hypersensitive response in plants remains limited. Here, we report the cloning and(More)
This paper aims to explore RLC equivalent circuit synthesis method for reduced-order models of interconnect circuits obtained by Krylov subspace based model order reduction (MOR) methods. To guarantee pure RLC equivalent circuits can be synthesized, both the structures of input and output incidence matrices and the block structure of the circuit matrices(More)
Through-Silicon Via (TSV) is a technology that enables vertical integration of silicon dies forming a single 3D-IC stack. In this paper, a practical model is proposed for the TSV assignment problem of the stacked-die 3D nets. We present the <i>first</i> work in the literature to prove that the general 3D-IC TSV assignment problem with more than two dies is(More)
Patients with ALK gene rearrangements often manifest dramatic responses to crizotinib, an ALK inhibitor. Accurate identification of patients with ALK-positive non-small cell lung cancer (NSCLC) is essential for the clinical application of ALK-targeted therapy. However, assessing EML4-ALK rearrangement in NSCLC remains challenging in routine pathology(More)
HOXD13, the homeobox-containing gene located at the most 5' end of the HOXD cluster, plays a critical role in limb development. It has been shown that mutations in human HOXD13 can give rise to limb malformations, with variable expressivity and a wide spectrum of clinical manifestations. Polyalanine expansions in HOXD13 cause synpolydactyly, whereas amino(More)
Circuit reliability is affected by various fabrication-time and run-time effects. Fabrication-induced process variation has significant impact on circuit performance and reliability. Various aging effects, such as negative bias temperature instability, cause continuous performance and reliability degradation during circuit run-time usage. In this work, we(More)
While double patterning lithography (DPL) is still in active development, triple or even quadruple patterning has recently been proposed for the next technology node. In this paper, we propose a pairwise coloring (PWC) method to tackle the layout decomposition problem for general multiple patterning lithography (MPL). The main idea is to reduce the problem(More)
EML4-ALK is a new driver gene of non-small cell lung cancer and a target of crizotinib. The objectives of this study were to determine the frequency of ALK rearrangements in a large cohort of patients with primary lung adenocarcinoma and to analyze the association of ALK rearrangements with clinicopathological characteristics and clinical outcomes. The(More)