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CHOP (GADD153) is a small nuclear protein that dimerizes avidly with members of the C/EBP family of transcription factors. Normally undetectable, it is expressed at high levels in cells exposed to conditions that perturb protein folding in the endoplasmic reticulum and induce an endoplasmic reticulum stress response. CHOP expression in stressed cells is(More)
Detecting hedges and their scope in natural language text is very important for information inference. In this paper, we present a system based on a cascade method for the CoNLL-2010 shared task. The system composes of two components: one for detecting hedges and another one for detecting their scope. For detecting hedges, we build a cascade subsystem.(More)
Cells modify their gene expression pattern in response to stress signals emanating from the endoplasmic reticulum (ER). The well-characterized aspect of this response consists of the activation of genes that encode protein chaperones and other ER resident proteins, and is conserved between mammals and yeast. In mammalian cells, however, ER stress also(More)
A single double-strand break (DSB) induced by HO endonuclease triggers both repair by homologous recombination and activation of the Mec1-dependent DNA damage checkpoint in budding yeast. Here we report that DNA damage checkpoint activation by a DSB requires the cyclin-dependent kinase CDK1 (Cdc28) in budding yeast. CDK1 is also required for DSB-induced(More)
Crosstalk noise is an intrinsic characteristic of photonic devices used by optical networks-on-chip (ONoCs) as well as a potential issue. For the first time, this paper analyzed and modeled the crosstalk noise, signal-to-noise ratio (SNR), and bit error rate (BER) of optical routers and ONoCs. The analytical models for crosstalk noise, minimum SNR, and(More)
—As benchmark programs for microprocessor archi-tectures, network-on-chip (NoC) traffic patterns are essential tools for NoC performance assessments and architecture explorations. The fidelity of NoC traffic patterns has profound influence on NoC studies. For the first time, this paper presents a realistic traffic benchmark suite, called MCSL, and the(More)
World Wide Web, the biggest distributed system ever built, experiences tremendous growth and change in Web sites, users, and technology. A realistic and accurate characterization of Web workload is the first, fundamental step in areas such as performance analysis and prediction, capacity planning, and admission control. Compared to the previous work, in(More)