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Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells
Stimulation of Hedgehog (Hh) signaling induces carcinogenesis or promotes cell survival in cancers of multiple organs. In epithelial cancer with aberrant Hedgehog activation, abrogation of Hedgehog… Expand
Panax Notoginseng flower saponins (PNFS) inhibit LPS-stimulated NO overproduction and iNOS gene overexpression via the suppression of TLR4-mediated MAPK/NF-kappa B signaling pathways in RAW264.7…
BackgroundPanax Notoginseng flower saponins (PNFS) are the main active component of Panax notoginseng (Burk) F. H. Chen flower bud (PNF) and possess significant anti-inflammatory efficacy. This study… Expand
Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages.
- Xu-dong Hu, Y. Yang, +8 authors Jian-ping Zuo
- Biology, Medicine
- Journal of ethnopharmacology
- 8 December 2008
AIM OF THE STUDY Fissistigma oldhamii (Hemsl.) Merr, a traditional Chinese herb medicine, is used for treating rheumatoid arthritis in China. In our previous study, an effective compound,… Expand
Discovery and Synthesis of New Immunosuppressive Alkaloids from the Stem of Fissistigma oldhamii (Hemsl.) Merr.
Repair of segmental long bone defect in a rabbit radius nonunion model: comparison of cylindrical porous titanium and hydroxyapatite scaffolds.
A segmental long bone defect in a rabbit radius nonunion model was repaired using cylindrical porous titanium (Ti) and hydroxyapatite (HA) scaffolds. Each scaffold was produced using the same method,… Expand
Preoperative Lymphoscintigraphy Predicts the Successful Identification but Is Not Necessary in Sentinel Lymph Nodes Biopsy in Breast Cancer
BackgroundAlthough preoperative lymphoscintigraphy in sentinel lymph node biopsy (SLNB) for breast cancer patients is undergone commonly, its clinical significance remains controversial.MethodsWe… Expand
Blockade of IKs by HMR 1556 increases the reverse rate‐dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles
- P. P. So, Xu-dong Hu, P. Backx, J. Puglisi, P. Dorian
- Chemistry, Medicine
- British journal of pharmacology
- 1 June 2006
1 The rate‐dependent contributions of the rapid and slow components of the cardiac delayed rectifier K+ current (IKr and IKs, respectively) to repolarization are not fully understood. It is unclear… Expand
Web-based data acquisition
The research work on Web-based long-distance data acquisition (DAQ) is valuable for application to tele-detection machine faults. With an expert system for machine fault detection, faults in a… Expand
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
- Y. Zhang, Xiang-Gen Zhong, Z. Zheng, Xu-dong Hu, Jian-ping Zuo, L. Hu
- Medicine, Chemistry
- Bioorganic & medicinal chemistry
- 15 January 2007
Three new alkaloids (1-3) and twenty-one known compounds were isolated from the stem of Fissistigma oldhamii (Hemsl.) Merr. which was the ruler herb in an approved Traditional Chinese herbal formula… Expand
Preventive effects of 1,25-(OH)2VD3 against ConA-induced mouse hepatitis through promoting vitamin D receptor gene expression
AbstractAim:To investigate the immunosuppressive effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2VD3) on concanavalin A (ConA)-induced hepatitis and elucidate the action mechanism.Methods:Female… Expand