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The concentrations of total mercury (Hg), methylmercury (MeHg) and total selenium (Se) were determined in muscle, liver and brain tissues of young-of-the-year walleye (Stizosedion vitreum) specimens collected from 8 boreal lakes that are located within 107km around the Sudbury smelters in Ontario, Canada. Dry weight basis concentrations of Hg were highest(More)
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA (miR) regulates this phenomenon. In this study, we investigated the function and mechanism of miR-203 in NPC radioresistance, one of downregulated miRs in the radioresistant NPC cells identified by our previous microarray analysis. We(More)
To identify the proteins involved in radioresistance in nasopharyngeal cancer (NPC) cells. Sublethal ionizing radiation was applied to establish a radioresistant NPC cell line from its parental NPC cell line CNE1. Clonogenic survival assay, cell growth assay and flow cytometry analysis were used to examine the difference of radiosensitivity in the(More)
BACKGROUND The purpose of this study was to identify miRNAs and genes involved in nasopharyngeal carcinoma (NPC) radioresistance, and explore the underlying mechanisms in the development of radioresistance. METHODS We used microarrays to compare the differences of both miRNA and mRNA expression profiles in the radioresistant NPC CNE2-IR and radiosensitive(More)
BACKGROUND/AIMS There is disagreement about the prognostic value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients who have stage I-III colorectal cancer. Therefore, we investigated the relationship between preoperative serum CEA and CA19-9 levels and clinical outcome in patients with this disease. METHODOLOGY The(More)
To discover novel lung adenocarcinoma (AdC) biomarkers, isobaric tags for relative and absolute quantitation (iTRAQ)-tagging combined with 2D-LC-MS/MS analysis was used to identify differentially expressed plasma membrane proteins in lung AdC and paired paraneoplastic normal lung tissues (PNLTs) adjacent to tumors. In this study, significant caveolin-1(More)
OBJECTIVE To identify proteins associated with nasopharyngeal carcinoma (NPC) metastasis, and provide scientific basis for the prevention and cure of NPC. METHODS A two-dimensional gel electrophoresis and mass spectrometry were performed to screen for differential proteins between highly metastatic 5-8F and non-metastatic 6-10B NPC cell lines. Western(More)
This paper presents four cases of pediatric extrasystole which did not fulfil the diagnostic criteria for parasystole. By calculating various ectopic intervals, we established the phase-response curve demonstrating that sinus electrotonic activities modulated the parasystolic focus in each case. Our results showed these cases to be modulated parasystole.
To develop in the increasingly fierce competitive environment for enterprise, technology innovation is indispensable. This thesis analyzed the industrial efficiency of SMES technology innovation with the method of factor analysis. The Analysis Results can show the industrial internal potential and management level, and discover some existing problems in(More)
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA regulates this phenomenon. In this study, we investigated the function and mechanism of miR-125b in NPC radioresistance, one of upregulated miRNAs in the radioresistant NPC cells identified by our previous microarray analysis. We observed(More)