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Marine-Derived Natural Lead Compound Disulfide-Linked Dimer Psammaplin A: Biological Activity and Structural Modification
Marine natural products are considered to be valuable resources that are furnished with diverse chemical structures and various bioactivities. To date, there are seven compounds derived from marine…
Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao
Based on the above results, the cell apoptosis induced by compound 19 in CaEs-17 cells was most probably involved in the intrinsic apoptotic pathway.
Recent Progress of Oridonin and Its Derivatives for the Treatment of Acute Myelogenous Leukemia.
Recent progress of the synthetic, physiological and pharmacological investigations of oridonin and its prodrug HAO472 are overviewed, aiming to disclose the therapeutic potentials and broaden the platform for new anticancer drugs discovery.
Lignans and triterpenoids from Vitex negundo var. heterophylla and their biological evaluation.
Hypoglycemic effect of silychristin A from Silybum marianum fruit via protecting pancreatic islet β cells from oxidative damage and inhibiting α-glucosidase activity in vitro and in rats with type 1…
Reduction-sensitive mixed micelles assembled from amphiphilic prodrugs for self-codelivery of DOX and DTX with synergistic cancer therapy.
Dehydrodiconiferyl alcohol from Silybum marianum (L.) Gaertn accelerates wound healing via inactivating NF‐κB pathways in macrophages
Findings preliminarily brought to light the promising therapeutic potential of DHCA in skin wound healing.
Rational Design of IR820- and Ce6-Based Versatile Micelle for Single NIR Laser-Induced Imaging and Dual-Modal Phototherapy.
- Xu Hu, Hailong Tian, Wei Jiang, Aixin Song, Zhonghao Li, Y. Luan
- Biology, ChemistrySmall
- 26 November 2018
The highly safe and effective TPGS-IR820/Ce6 micelles can offer an innovative strategy to construct single NIR light-induced PTT and PDT combined phototherapy nanoplatforms via suitable modification of organic phototherapeutic agents.
Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound
- Dahong Li, Tong Han, Jinyi Xu
- Chemistry, BiologyInternational journal of molecular sciences
- 24 August 2016
The synthetic medicinal chemistry work of oridonin is summarized from the first publication 40 years ago and the research experience of the molecule for about 10 years is shared, which may provide useful information to those who are interested in this research field.