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miR-203 inhibits the proliferation and self-renewal of esophageal cancer stem-like cells by suppressing stem renewal factor Bmi-1.
- Xiying Yu, Xingran Jiang, H. Li, L. Guo, W. Jiang, S. Lu
- Biology, Medicine
- Stem cells and development
- 15 March 2014
Cancer stem-like cells exist in many malignancies and several stem cell-related genes and microRNAs, such as Bmi-1 and miR-203, have been identified as cancer stem-like cell regulators using gene… Expand
TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141
Cancer stem-like cells have been identified in primary human tumors and cancer cell lines. Previously we found TM4SF1 gene was highly expressed in side population (SP) cells from esophageal squamous… Expand
MicroRNA‐1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma
A short tandem repeat (STR) polymorphism in the 3′UTR region of esophageal cancer‐related gene 2 (ECRG2, also known as SPINK7) has been widely reported to be associated with the incidence and the… Expand
53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells
BackgroundMutations in DNA damage response factors BRCA1 and BRCA2 confer sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors in breast and ovarian cancers. BRCA1/BRCA2-defective tumors can… Expand
DUSP6, a tumor suppressor, is involved in differentiation and apoptosis in esophageal squamous cell carcinoma
Dual-specificity phosphatase 6 (DUSP6), a specific negative feedback regulator of phosphorylated extracellular signal-regulated kinase, was found to play an important role in numerous types of solid… Expand
Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway.
Metformin is a widely used anti-diabetic drug for the management of type 2 diabetes mellitus. Recently, epidemiological studies demonstrate that metformin has anti-cancer effects on esophageal… Expand
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells
Cancer stem cells (CSCs) have been isolated from many tumors and considered as the main reason of cancer recurrence and metastasis. DNA methyltransferase 1 (DNMT1) mediates DNA methylation and plays… Expand
MicroRNA-429 inhibits bone metastasis in breast cancer by regulating CrkL and MMP-9.
Bone metastasis is common in late-stage breast cancer patients and leads to skeletal-related events that affect the quality of life and decrease survival. Numerous miRNAs have been confirmed to be… Expand
Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
The clinical outcome of neuroblastoma (NB) has significantly improved in the last 30 years for patients with localized disease; however, the overall survival (OS) for patients with metastasis remains… Expand
Abstract 3756: MiR-203 inhibits the proliferation and self-renewals of esophageal cancer stem-like cells by suppression stem renewal factor Bmi-1.
Recent reports have shown that cancer stem-like cells exist in many malignancies and several stem cell-related gene products and miRNAs, such as Bmi-1 and miR-203, were identified as cancer stem-like… Expand