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miR-203 inhibits the proliferation and self-renewal of esophageal cancer stem-like cells by suppressing stem renewal factor Bmi-1.
Cancer stem-like cells exist in many malignancies and several stem cell-related genes and microRNAs, such as Bmi-1 and miR-203, have been identified as cancer stem-like cell regulators using geneExpand
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TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141
Cancer stem-like cells have been identified in primary human tumors and cancer cell lines. Previously we found TM4SF1 gene was highly expressed in side population (SP) cells from esophageal squamousExpand
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MicroRNA‐1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma
A short tandem repeat (STR) polymorphism in the 3′UTR region of esophageal cancer‐related gene 2 (ECRG2, also known as SPINK7) has been widely reported to be associated with the incidence and theExpand
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53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells
BackgroundMutations in DNA damage response factors BRCA1 and BRCA2 confer sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors in breast and ovarian cancers. BRCA1/BRCA2-defective tumors canExpand
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DUSP6, a tumor suppressor, is involved in differentiation and apoptosis in esophageal squamous cell carcinoma
Dual-specificity phosphatase 6 (DUSP6), a specific negative feedback regulator of phosphorylated extracellular signal-regulated kinase, was found to play an important role in numerous types of solidExpand
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Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway.
Metformin is a widely used anti-diabetic drug for the management of type 2 diabetes mellitus. Recently, epidemiological studies demonstrate that metformin has anti-cancer effects on esophagealExpand
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DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells
Cancer stem cells (CSCs) have been isolated from many tumors and considered as the main reason of cancer recurrence and metastasis. DNA methyltransferase 1 (DNMT1) mediates DNA methylation and playsExpand
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MicroRNA-429 inhibits bone metastasis in breast cancer by regulating CrkL and MMP-9.
Bone metastasis is common in late-stage breast cancer patients and leads to skeletal-related events that affect the quality of life and decrease survival. Numerous miRNAs have been confirmed to beExpand
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Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
The clinical outcome of neuroblastoma (NB) has significantly improved in the last 30 years for patients with localized disease; however, the overall survival (OS) for patients with metastasis remainsExpand
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Abstract 3756: MiR-203 inhibits the proliferation and self-renewals of esophageal cancer stem-like cells by suppression stem renewal factor Bmi-1.
Recent reports have shown that cancer stem-like cells exist in many malignancies and several stem cell-related gene products and miRNAs, such as Bmi-1 and miR-203, were identified as cancer stem-likeExpand
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