Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway
- Meihui Chen, Min Tan, R. Pi
- Biology, ChemistryMetabolic brain disease
- 1 February 2015
Results indicate that BBR protects HCA-induced HT-22 cell death partly via modulating Akt pathway, suggesting BBR may be a promising therapeutic agent for the treatment of H CA-related diseases, including AD.
A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease.
- Xiao Zhang, Xixin He, Qiuhe Chen, Junfeng Lu, S. Rapposelli, R. Pi
- BiologyBioorganic & Medicinal Chemistry
- 1 December 2017
Novel cytotoxic nine-membered macrocyclic polysulfur cembranoid lactones from the soft coral Sinularia sp.
- Ling-fang Lei, Min-feng Chen, Cui‐Xian Zhang
- Chemistry
- 23 September 2014
Identification of UQCRB as an oxymatrine recognizing protein using a T7 phage display screen.
- Yanhua Sun, Xiao-Yuan Zhang, Ren Zhang
- Chemistry, BiologyJournal of Ethnopharmacology
- 4 December 2016
Oxyresveratrol from Mulberry as a dihydrate
- H. Deng, Xixin He, Yujuan Xu, Xiaopeng Hu
- ChemistryActa Crystallographica Section E
- 6 April 2012
The title compound, C14H12O4·2H2O, a derivative of resveratrol, was isolated from mulberry and found the linking C=C double bond has a trans conformation and allows the formation of a conjugated system throughout the molecule.
Arborinol methyl ether from Areca catechu L.
- Xixin He, Yajun Li, Cui‐Xian Zhang, Xiaopeng Hu
- ChemistryActa Crystallographica Section E
- 11 August 2010
The title compound isolated from Areca catechu L. (common name: arborinol methyl ether; a member of the arborane family) was established as 3α-methoxyarbor-9(11)-ene, C31H52O, with absolute configuration 3R,5R,8S,10S,13R,14S,17S,18S, 21S.
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
- Xiao-juan Chao, Xixin He, R. Pi
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 1 October 2012
Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia.
- Jinhao Liang, Yi-You Huang, Hai-bin Luo
- Biology, ChemistryJournal of Medicinal Chemistry
- 2 March 2020
To validate PDE4 inhibitors as novel therapeutic agents against vascular dementia (VaD), twenty-five derivatives were discovered from the natural inhibitor α-mangostin, with remarkable therapeutic effects in a VaD model and did not cause emesis to beagle dogs, indicating its potential as a novel anti-VaD agent.
Effect of Tacrine‐3‐caffeic Acid, A Novel Multifunctional Anti‐Alzheimer's Dimer, Against Oxidative‐Stress‐Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO‐1 Pathway
- Xiao-juan Chao, Zi-wei Chen, R. Pi
- BiologyCNS Neuroscience & Therapeutics
- 1 September 2014
This study was designed to uncover the cellular and biochemical mechanisms underlying the neuroprotective effects of tacrine‐3‐caffeic acid (T3CA), a novel promising multifunctional anti‐Alzheimer's dimer, against OS‐induced neuronal death.
The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay.
- P. Zhao, Shang-ke Chen, Hai-bin Luo
- Biology, ChemistryBiochimica et Biophysica Acta
- 1 October 2013
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