Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway
Results indicate that BBR protects HCA-induced HT-22 cell death partly via modulating Akt pathway, suggesting BBR may be a promising therapeutic agent for the treatment of H CA-related diseases, including AD.
A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease.
Novel cytotoxic nine-membered macrocyclic polysulfur cembranoid lactones from the soft coral Sinularia sp.
Identification of UQCRB as an oxymatrine recognizing protein using a T7 phage display screen.
Oxyresveratrol from Mulberry as a dihydrate
The title compound, C14H12O4·2H2O, a derivative of resveratrol, was isolated from mulberry and found the linking C=C double bond has a trans conformation and allows the formation of a conjugated system throughout the molecule.
Arborinol methyl ether from Areca catechu L.
- Xixin He, Yajun Li, Cui‐Xian Zhang, Xiaopeng Hu
- ChemistryActa Crystallographica Section E
- 11 August 2010
The title compound isolated from Areca catechu L. (common name: arborinol methyl ether; a member of the arborane family) was established as 3α-methoxyarbor-9(11)-ene, C31H52O, with absolute configuration 3R,5R,8S,10S,13R,14S,17S,18S, 21S.
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia.
To validate PDE4 inhibitors as novel therapeutic agents against vascular dementia (VaD), twenty-five derivatives were discovered from the natural inhibitor α-mangostin, with remarkable therapeutic effects in a VaD model and did not cause emesis to beagle dogs, indicating its potential as a novel anti-VaD agent.
Effect of Tacrine‐3‐caffeic Acid, A Novel Multifunctional Anti‐Alzheimer's Dimer, Against Oxidative‐Stress‐Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO‐1 Pathway
This study was designed to uncover the cellular and biochemical mechanisms underlying the neuroprotective effects of tacrine‐3‐caffeic acid (T3CA), a novel promising multifunctional anti‐Alzheimer's dimer, against OS‐induced neuronal death.
The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay.