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The recruitment of DNA ligase I to replication foci and the efficient joining of Okazaki fragments is dependent on the interaction between DNA ligase I and proliferating cell nuclear antigen (PCNA). Although the PCNA sliding clamp tethers DNA ligase I to nicked duplex DNA circles, the interaction does not enhance DNA joining. This suggests that other(More)
3D printers have become popular in recent years and enable fabrication of custom objects for home users. However, the cost of the material used in printing remains high. In this paper, we present an automatic solution to design a skin-frame structure for the purpose of reducing the material cost in printing a given 3D object. The frame structure is designed(More)
In this paper, we present a robust normal estimation algorithm based on the low-rank subspace clustering technique. The main idea is based on the observation that compared with the points around sharp features, it is relatively easier to obtain accurate normals for the points within smooth regions. The points around sharp features and smooth regions are(More)
MicroRNAs are endogenous small non-coding RNAs that regulate gene expression and cancer development. A rare population of hepatocellular cancer stem cells (HSCs) holds the extensive proliferative and self-renewal potential necessary to form a liver tumour. We postulated that specific transcriptional factors might regulate the expression of microRNAs and(More)
BACKGROUND Cortical neurons implement a high frequency-specific modulation of subcortical nuclei that includes the cochlear nucleus. Anatomical studies show that corticofugal fibers terminating in the auditory thalamus and midbrain are mostly ipsilateral. Differently, corticofugal fibers terminating in the cochlear nucleus are bilateral, which fits to the(More)
Resistance to tamoxifen (Tam), a widely used antagonist of the estrogen receptor (ER), is a common obstacle to successful breast cancer treatment. While adjuvant therapy with Tam has been shown to significantly decrease the rate of disease recurrence and mortality, recurrent disease occurs in one third of patients treated with Tam within 5 years of therapy.(More)
We present a global method for consistently orienting a defective raw point set with noise, non-uniformities and thin sharp features. Our method seamlessly combines two simple but effective techniques—constrained Laplacian smoothing and visibility voting—to tackle this challenge. First, we apply a Laplacian contraction to the given point cloud, which(More)
Semantic mesh segmentation and labeling is a fundamental problem in graphics. Conventional data-driven approaches usually employ a tedious offline pre-training process. Moreover, the number and especially the quality of the manually labeled examples challenge such strategies. In this paper, we develop a low-rank representation model with structure guiding(More)
The transforming growth factor-β (TGF-β) signaling pathway is believed to contribute to carcinoma development by increasing cell invasiveness and metastasis and inducing the epithelial-to-mesenchymal transition (EMT). Protein phosphatase PPM1A has been reported to dephosphorylate TGF-β-activated Smad2/3, thus inhibiting the TGF-β signaling pathway. In this(More)
The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the general usefulness of the mouse,(More)