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BACKGROUND Diabetes is associated with genetic susceptibility, and family history is a risk factor. The study investigated the association between different family history risk levels and the prevalence of diabetes in a multi high-risk cohort and evaluated the impact of family history of diabetes on insulin secretion and insulin sensitivity. MATERIALS AND(More)
According to previous literature, pYEEI and AcpYEEI also have high affinity with the SH2 domain specifically. However, up to now, few researches pay attention to the interaction difference between these two phosphopeptides which is caused by the N-terminal acetylation. In this paper, the competitive interaction between the SH2 domain and phosphopeptides(More)
OBJECTIVE To establish a rapid, accurate, noninvasive and low cost method for screening MT3243A>G mutation in mitochondrial diabetes. METHODS Blood, saliva, and urine sediment samples were collected from 6 patients with confirmed mitochondrial diabetes and 50 healthy controls from Shanghai Children's Hospital and Shanghai Sixth People's Hospital. The(More)
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