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Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq
During mammalian pre-implantation embryo development, when the first asymmetry emerges and how it develops to direct distinct cell fates remain longstanding questions. Here, by analyzing… Expand
Effect of feedback regulation on stochastic gene expression.
Stochastic noise in gene expression arises as a result of species in small copy number undergoing transitions between discrete chemical states. Here the noise in a single gene network is investigated… Expand
Additivity of noise propagation in a protein cascade.
Stochastic fluctuations in a protein synthetic cascade are investigated using standard Omega-expansion technique. For the steady-state sensitivity, we show the conditions that result in the… Expand
Effects of bidirectional regulation on noises in gene networks.
To investigate the effects of bidirectional regulation on the noise in protein concentration, a theoretical and simple three-gene network model is considered. The basic idea behind this model is from… Expand
Stochastic fluctuations in frequency-dependent selection: a one-locus, two-allele and two-phenotype model.
- Yi Tao, R. Cressman, B. Zhang, Xiudeng Zheng
- Biology, Medicine
- Theoretical population biology
- 1 October 2008
Stochastic fluctuations in a simple frequency-dependent selection model with one-locus, two-alleles and two-phenotypes are investigated. The steady-state statistics of allele frequencies for an… Expand