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Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-κB-Mediated Inflammatory Responses
TLDR
It is shown that PF treatment for 14 days could significantly inhibit transient middle cerebral artery occlusion (MCAO)-induced over-activation of astrocytes and microglia, and prevented up-regulations of pro-inflamamtory mediators in plasma and brain. Expand
Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes
TLDR
It was demonstrated that lack of aquaporin-4 down-regulated astrocytic expression of GLT-1 but not of glutamate/aspartate transporter (GLAST) was demonstrated, providing direct evidences for the first time that aquaporIn-4 plays an important role in the function of glutamate transporters. Expand
Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation
TLDR
This study indicates that UCP2 expressed in astrocytes modulates ER stress and neuroinflammation, and is crucial for the survival of dopaminergic neuron in the pathogenesis of PD. Expand
Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice
TLDR
It is demonstrated that metabolic inflammation exacerbates DA neuronal degeneration in the progress of PD, which will provide a novel insight into the etiology of PD. Expand
Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activity
  • Y. Yu, M. Zhong, +4 authors G. Zhu
  • Chemistry, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • 27 March 2007
TLDR
Results suggested that endogenous H2O2 in the PVN mediated both the CSAR and Ang II-induced CSAR enhancement responses, which were involved in regulating sympathetic activity and arterial pressure. Expand
Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS‐dependent AMPK‐TSC‐mTOR Signaling Pathway
TLDR
The impact of resveratrol on the antitumor effects of temozolomide (TMZ), a standard treatment regiment of glioblastoma (GBM), in vitro and in vivo is investigated. Expand
Sex‐ and region‐specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin‐4 knockout mice
  • Yi Fan, J. Zhang, +6 authors G. Hu
  • Biology, Medicine
  • Journal of neuroscience research
  • 15 November 2005
TLDR
Results provide the first evidence that the lack of AQP4 expression is accompanied by sex‐ and region‐specific alterations in brain amino acid and monoamine metabolism. Expand
KATP Channel Openers Facilitate Glutamate Uptake by GluTs in Rat Primary Cultured Astrocytes
TLDR
Activation of KATP channel, especially mitochondrial KATp channel, improves the function of GluTs in astrocytes due to reducing ROS production and downregulating PKC phosphorylation, which provides a new strategy for neuroprotection. Expand
Antagonizing peroxisome proliferator‐activated receptor γ facilitates M1‐to‐M2 shift of microglia by enhancing autophagy via the LKB1–AMPK signaling pathway
TLDR
It is observed that antagonizing PPARγ promoted LPS‐stimulated changes in polarization from the M1 to the M2 phenotype in primary microglia, which might be due to improved autophagy via the activation of the LKB1–AMPK signaling pathway. Expand
AQP4 Knockout Aggravates Ischemia/Reperfusion Injury in Mice
TLDR
Findings provide direct evidence that AQP4 plays a crucial role in the pathogenesis of I/R injury, which may confer a new option for stroke treatment, and suggest an involvement of AQP 4 in astrocytic dysfunction. Expand
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