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Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum
  • S. Brown, A. Guss, +13 authors L. Lynd
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 8 August 2011
Clostridium thermocellum is a thermophilic, obligately anaerobic, Gram-positive bacterium that is a candidate microorganism for converting cellulosic biomass into ethanol through consolidatedExpand
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Closing the carbon balance for fermentation by Clostridium thermocellum (ATCC 27405).
Our lab and most others have not been able to close a carbon balance for fermentation by the thermophilic, cellulolytic anaerobe, Clostridium thermocellum. We undertook a detailed accounting ofExpand
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Simultaneous saccharification and co‐fermentation of paper sludge to ethanol by Saccharomyces cerevisiae RWB222—Part I: Kinetic modeling and parameters
A kinetic model was developed to predict batch simultaneous saccharification and co‐fermentation (SSCF) of paper sludge by the xylose‐utilizing yeast Saccharomyces cerevisiae RWB222 and theExpand
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Simultaneous saccharification and co‐fermentation of paper sludge to ethanol by Saccharomyces cerevisiae RWB222. Part II: Investigation of discrepancies between predicted and observed performance at
The simultaneous saccharification and co‐fermentation (SSCF) kinetic model described in the companion paper can predict batch and fed batch fermentations well at solids concentrations up to 62.4 g/LExpand
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Kinetic modeling of cellulosic biomass to ethanol via simultaneous saccharification and fermentation: Part I. Accommodation of intermittent feeding and analysis of staged reactors
The model of South et al. [South et al. (1995) Enzyme Microb Technol 17(9): 797–803] for simultaneous saccharification of fermentation of cellulosic biomass is extended and modified to accommodateExpand
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Enzyme inactivation by ethanol and development of a kinetic model for thermophilic simultaneous saccharification and fermentation at 50 °C with Thermoanaerobacterium saccharolyticum ALK2
Studies were undertaken to understand phenomena operative during simultaneous saccharification and fermentation (SSF) of a model cellulosic substrate (Avicel) at 50°C with enzymatic hydrolysisExpand
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Winter rye as a bioenergy feedstock: impact of crop maturity on composition, biological solubilization and potential revenue
BackgroundWinter annual crops such as winter rye (Secale cereale L) can produce biomass feedstock on seasonally fallow land that continues to provide high-value food and feed from summer annuals suchExpand
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Conversion for Avicel and AFEX pretreated corn stover by Clostridium thermocellum and simultaneous saccharification and fermentation: insights into microbial conversion of pretreated cellulosic
In this study, efforts were taken to compare solubilization of Avicel and AFEX pretreated corn stover (AFEX CS) by SSF and Clostridium thermocellum fermentation, with an aim to gain insights intoExpand
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Kinetic modeling of cellulosic biomass to ethanol via simultaneous saccharification and fermentation: Part II. Experimental validation using waste paper sludge and anticipation of CFD analysis
A kinetic model of cellulosic biomass conversion to ethanol via simultaneous saccharification and fermentation (SSF) developed previously was validated experimentally using paper sludge as theExpand
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Determining the roles of the three alcohol dehydrogenases (AdhA, AdhB and AdhE) in Thermoanaerobacter ethanolicus during ethanol formation
Thermoanaerobacter ethanolicus is a promising candidate for biofuel production due to the broad range of substrates it can utilize and its high ethanol yield compared to other thermophilic bacteria,Expand
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