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Thyroid hormones have been shown to regulate breast cancer cells growth, the absence or reduction of thyroid hormones in cells could provoke a proliferation arrest in G0-G1 or weak mitochondrial activity, which makes cells insensitive to therapies for cancers through transforming into low metabolism status. This biological phenomenon may help explain why(More)
One-step multiple gene disruption in the model organism Saccharomyces cerevisiae is a highly useful tool for both basic and applied research, but it remains a challenge. Here, we report a rapid, efficient, and potentially scalable strategy based on the type II Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated proteins(More)
The Internet of Things (IoT), which enables common objects to be intelligent and interactive, is considered the next evolution of the Internet. Its pervasiveness and abilities to collect and analyze data which can be converted into information have motivated a plethora of IoT applications. For the successful deployment and management of these applications,(More)
The fitness of the rape leaf is closely related to its biomass and photosynthesis. The study of leaf traits is significant for improving rape leaf production and optimizing crop management. Canopy structure and individual leaf traits are the major indicators of quality during the rape seedling stage. Differences in canopy structure reflect the influence of(More)
Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses(More)
A random sample of pairs of animal feeds and manures were collected from 215 animal barns in Beijing and Fuxin regions of China. The concentrations of Cd in manures and feeds ranged from non-detectable to 129.8 mg/kg dry weight and non-detectable to 31 mg/kg dry weight, respectively. The concentrations of Cd in pig, dairy cow and chicken manures were(More)
Mitochondrial diseases include a group of maternally inherited genetic disorders caused by mutations in mtDNA. In most of these patients, mutated mtDNA coexists with wild-type mtDNA, a situation known as mtDNA heteroplasmy. Here, we report on a strategy toward preventing germline transmission of mitochondrial diseases by inducing mtDNA heteroplasmy shift(More)
Transcription activator-like effector nucleases (TALENs) have rapidly emerged as a powerful genome editing tool. The site-specific DNA double-strand breaks generated by TALENs in the human chromosome can induce homologous recombination or non-homologous end joining, resulting in desired genetic modifications. In this study, we report the development of a(More)
Unlike a traditional social network service, a microblogging network like Twitter is a hybrid network, combining aspects of both social networks and information networks. Understanding the structure of such hybrid networks and to predict new links are important for many tasks such as friend recommendation, community detection, and network growth models. In(More)