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Effects of an antibody to interleukin-5 in a monkey model of asthma.
To investigate the role of interleukin-5 (IL-5) on airway hyperreactivity and pulmonary inflammation in nonhuman primate airways, the effect of a neutralizing monoclonal antibody to murine IL-5Expand
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Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma.
To investigate the role of IL-5 in airway hyperreactivity and pulmonary eosinophilia, we used a model of allergic asthma in guinea pigs and a neutralizing monoclonal antibody (TRFK-5) directedExpand
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Role of nitric oxide on eosinophilic lung inflammation in allergic mice.
Nitric oxide (NO) is an important mediator of inflammatory reactions and may contribute to the lung inflammation in allergic pulmonary diseases. To assess the role of NO in pulmonary inflammation, weExpand
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TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs
We examined the molecular pharmacology and in vivo effects of a TRPV1 receptor antagonist, N-(4-Tertiarybutylphenyl)-4(3-cholorphyridin-2-yl)-tetrahydro-pyrazine1(2H) – carboxamide (BCTC) on theExpand
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Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung.
Based on its involvement in eosinophil biology, interleukin 5 (IL-5) may play a role in the pulmonary eosinophilia associated with allergic reactions. We have examined that hypothesis using aExpand
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Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity.
This report describes the development and the biology of Sch 55700, a humanized monoclonal antibody to human IL-5 (hIL-5). Sch 55700 was synthesized using CDR (complementarity determining regions)Expand
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Claudin 4-targeted protein incorporated into PLGA nanoparticles can mediate M cell targeted delivery.
Polymer-based microparticles are in clinical use mainly for their ability to provide controlled release of peptides and compounds, but they are also being explored for their potential to deliverExpand
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Mechanisms of allergic pulmonary eosinophilia in the mouse.
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SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist.
Experiments were performed to characterize the pharmacology of SCH 206272Expand
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Sulfur-dioxide exposure increases TRPV1-mediated responses in nodose ganglia cells and augments cough in guinea pigs.
The objective of the present experiments was to study the effects of pulmonary inflammation induced by subacute Sulfur-dioxide (SO(2)) exposure on capsaicin-induced responses in isolated primaryExpand
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