Xinyuan Chen

Mei X. Wu2
Apostolos Doukas1
Bill Farinelli1
R. Rox Anderson1
Soo Young Park1
2Mei X. Wu
1Apostolos Doukas
1Bill Farinelli
1R. Rox Anderson
1Soo Young Park
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BACKGROUND Development of a potent vaccine adjuvant without introduction of any side effects remains an unmet challenge in the field of the vaccine research. METHODOLOGY/PRINCIPAL FINDINGS We found that laser at a specific setting increased the motility of antigen presenting cells (APCs) and immune responses, with few local or systemic side effects. This(More)
RNA-directed DNA methylation in Arabidopsis thaliana is driven by the plant-specific RNA Polymerase IV (Pol IV). It has been assumed that a Pol IV transcript can give rise to multiple 24-nt small interfering RNAs (siRNAs) that target DNA methylation. Here, we demonstrate that Pol IV-dependent RNAs (P4RNAs) from wild-type Arabidopsis are surprisingly short(More)
In this paper, a new method involving an experiment in vivo and hydro-mechanical coupling simulations was proposed to investigate the biomechanical property of human periodontal ligament (PDL). Teeth were loaded and their displacements were measured in vivo. The finite element model of the experiment was built and hydro-mechanical coupling simulations were(More)
There is an urgent need of adjuvants for cutaneous vaccination. Here, we report that micro-sterile inflammation induced at inoculation sites can augment immune responses to influenza vaccines in animal models. The inoculation site is briefly illuminated with a handheld, non-ablative fractional laser before the vaccine is intradermally administered, which(More)
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