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A significant hallmark of Alzheimer's disease is the formation of senile plaques in the brain due to the unbalanced levels of amyloid-beta (Aβ). However, although how Aβ is produced from amyloid precursor proteins is well understood, little is known regarding the clearance and metabolism of various Aβ aggregates from the brain. Similarly, little is known(More)
Despite the increasing number of regulatory proteins identified in clathrin-independent endocytic (CIE) pathways, our understanding of the exact functions of these proteins and the sequential manner in which they function remains limited. In this study, using the Caenorhabditis elegans intestine as a model, we observed a unique structure of interconnected(More)
BACKGROUND Rosids are a major clade in the angiosperms containing 13 orders and about one-third of angiosperm species. Recent molecular analyses recognized two major groups (i.e., fabids with seven orders and malvids with three orders). However, phylogenetic relationships within the two groups and among fabids, malvids, and potentially basal rosids(More)
—The wide viewing angle technologies for liquid crystal displays (LCDs) are reviewed. The most promising liquid crystal modes for wide view technologies, such as in-plane switching, mul-tidomain vertical alignment, patterned vertical alignment, and advanced super view are compared. By optimizing the phase-compensation films and their device configurations,(More)
Datacenter networking has gained increasing popularity in the past few years. While researchers paid considerable efforts to enhance the performance and scalability of datacenter networks, achieving reliable data delivery in these emerging networks with misbehaving routers and switches received far less attention. Unfortunately, documented incidents of(More)
Analysis of large data sets can help resolve difficult nodes in the tree of life and also reveal complex evolutionary histories. The placement of the Celastrales-Oxalidales-Malpighiales (COM) clade within Rosidae remains one of the most confounding phylogenetic questions in angiosperms, with previous analyses placing it with either Fabidae or Malvidae. To(More)
BACKGROUND Plants contain numerous Su(var)3-9 homologues (SUVH) and related (SUVR) genes, some of which await functional characterization. Although there have been studies on the evolution of plant Su(var)3-9 SET genes, a systematic evolutionary study including major land plant groups has not been reported. Large-scale phylogenetic and evolutionary analyses(More)