Xinyu He

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PURPOSE The aim of this study was to map the disease locus of autosomal dominant cataracts (ADC) in a Chinese family. METHODS A four-generation family with multiple individuals affected by ADC was investigated. Genomic DNA was collected from 22 family members. A gene-scan at known candidate ADC loci was performed. To achieve fine-mapping we genotyped(More)
BACKGROUND Populus is an ecologically and economically important genus of trees, but distinguishing between wild species is relatively difficult due to extensive interspecific hybridization and introgression, and the high level of intraspecific morphological variation. The DNA barcoding approach is a potential solution to this problem. (More)
This study presents an efficient approach for large-scale data training. To deal with the rapid growth of training complexity for big data analysis, a novel mechanism, which utilizes fast kernel ridge regression (Fast KRR) and ridge support vector machines (Ridge SVMs), is proposed in this study. Firstly, Fast KRR based on low-order intrinsic-space(More)
—In modern embedded systems, the C2RTL (high-level synthesis) technology helps the designer to greatly reduce time-to-market, while satisfying the performance and cost constraints. To attack the performance challenges in complex designs, we propose a FIFO-connected hierarchical approach to replace the traditional flatten one in stream applications.(More)
A sufficient condition is derived for a finite-time L 2 singularity of the 3d incompressible Euler equations, making appropriate assumptions on eigenvalues of the Hessian of pressure. Under this condition lim t→T * sup Dω Dt L 2 (Ω) = ∞, where Ω ⊂ R 3 moves with the fluid. In particular, |ω|, |S ij | , and |P ij | all become unbounded at one point (x 1 , T(More)
Piebaldism is a rare autosomal dominant disorder of melanocyte development, which is mostly caused by KIT gene. The key characteristics of piebaldism include localized poliosis, congenital leukoderma, and other variable manifestations. The previous study has illustrated that the homogeneous MC1R (a gene which is associated with the hair color) variant(More)
Cancer metastasis accounts for the high mortality of many types of cancer. Owing to the unique advantages of high specificity and minimal invasiveness, photothermal therapy (PTT) has been evidenced with great potential in treating cancer metastasis. In this review, we outline the current approaches of PTT with respect to its application in treating(More)
Cancer metastasis is the leading reason for the high mortality of breast cancer. Herein, we report on a pH-responsive host-guest nanosystem of succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve the therapeutic efficacy on lung metastasis of breast cancer. PHN was composed of the host polymer of β-cyclodextrin linked with multiple(More)
Automatic C-to-RTL (C2RTL) synthesis can greatly benefit hardware design for streaming applications. However, stringent throughput/area constraints, especially the demand for power optimization at the system level is rather challenging for existing C2RTL synthesis tools. This paper considers a power-aware C2RTL framework using voltage-frequency islands(More)