Xinyu He

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BACKGROUND Populus is an ecologically and economically important genus of trees, but distinguishing between wild species is relatively difficult due to extensive interspecific hybridization and introgression, and the high level of intraspecific morphological variation. The DNA barcoding approach is a potential solution to this problem. (More)
PURPOSE The aim of this study was to map the disease locus of autosomal dominant cataracts (ADC) in a Chinese family. METHODS A four-generation family with multiple individuals affected by ADC was investigated. Genomic DNA was collected from 22 family members. A gene-scan at known candidate ADC loci was performed. To achieve fine-mapping we genotyped(More)
—In modern embedded systems, the C2RTL (high-level synthesis) technology helps the designer to greatly reduce time-to-market, while satisfying the performance and cost constraints. To attack the performance challenges in complex designs, we propose a FIFO-connected hierarchical approach to replace the traditional flatten one in stream applications.(More)
Cancer metastasis accounts for the high mortality of many types of cancer. Owing to the unique advantages of high specificity and minimal invasiveness, photothermal therapy (PTT) has been evidenced with great potential in treating cancer metastasis. In this review, we outline the current approaches of PTT with respect to its application in treating(More)
Developing circuits for streaming applications written in C (or its variants) can benefit greatly from C-to-RTL (C2RTL) synthesis. Yet, most existing C2RTL tools lack system-level options to trade off various design constraints, such as delay and area. This article introduces a systematic way to accomplish C2RTL synthesis for streaming applications(More)
Cancer metastasis is the leading reason for the high mortality of breast cancer. Herein, we report on a pH-responsive host-guest nanosystem of succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve the therapeutic efficacy on lung metastasis of breast cancer. PHN was composed of the host polymer of β-cyclodextrin linked with multiple(More)
Infantile cystinosis (IC) is a rare autosomal recessive disorder characterized by a defect in the lysosomal-membrane transport protein, cystinosin. It serves as a prototype for lysosomal transport disorders. To date, several CTNS mutations have been identified as the cause of the prototypic disease across different ethnic populations worldwide. However, in(More)
This study presents an efficient approach for large-scale data training. To deal with the rapid growth of training complexity for big data analysis, a novel mechanism, which utilizes fast kernel ridge regression (Fast KRR) and ridge support vector machines (Ridge SVMs), is proposed in this study. Firstly, Fast KRR based on low-order intrinsic-space(More)