Xinxiu Wang

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The orphan G protein-coupled receptor 37 (GPR37) is homologous to endothelin (ETB-R) and bombesin (GRP-R, NMB-R) receptors. The present study was undertaken to determine the expression and functional significance of GPR37 in human multiple myeloma (MM). We found that GPR37 was lowly expressed in MM cell adhesion model and highly expressed in proliferating(More)
Far Upstream Element (FUSE) Binding Protein 1 (FBP1), first identified as a single-stranded DNA (ssDNA) binding protein that binds to the FUSE, could modulate c-myc mRNA levels and also has been shown to regulate tumor cell proliferation and replication of virus. Typically, FBP1 could active the translation of p27kip1 (p27) and participate in tumor growth.(More)
Human hepatocellular carcinoma (HCC) is one of the most common fatal cancers and an important health problem worldwide, but its mechanism is still unclear. Microtubule (MT) kinesin motor proteins orchestrate a variety of cellular processes (e.g. mitosis, motility and organelle transportation) and have been involved in human carcinogenesis. KIF3B, the(More)
Cyclic AMP response element-binding protein (CREB) family can regulate biological functions of various types of cells and has relation with esophageal cancer cell migration and invasion. Cyclic AMP response element modulator-1 (CREM-1) is one member of the family with limited acquaintance. This study was conducted to investigate the effect of CREM-1 on(More)
In nature, population dynamics are subject to multiple sources of stochasticity. State-space models (SSMs) provide an ideal framework for incorporating both environmental noises and measurement errors into dynamic population models. In this paper, we present a recently developed method, Particle Markov Chain Monte Carlo (Particle MCMC), for parameter(More)
Spatial aggregation and self-similarity are two important properties in species spatial distribution analysis and modeling. The aggregation parameter k in the negative binomial distribution model and fractal dimension are two widely used measures of spatial aggregation and self-similarity, respectively. In this paper, we attempt to describe spatial(More)
AIMS Current treatments for the most common form of brain tumor, glioma, are disappointing in their effectiveness. Low expression levels of GART, an enzyme in the core nucleotide metabolism, significantly correlate with chemosensitivity, conferring a survival advantage to tumor cells. Our study aimed to explore the expression and function of GART in glioma.(More)
GPR37, also known as parkin-associated endothelin-like receptor (Pael-R), is an orphan G protein-coupled receptor (GPCR). It has been reported that GPCRs play vital roles in the development and progression of cancer. To investigate the potential roles of GPR37 in hepatocellular carcinoma (HCC), expression of GPR37 was examined in human HCC samples.(More)
Stochastic dynamical systems have been increasingly used in natural sciences. Data assimilation, which can effectively combine observation data and theoretical models, improves the applicability of dynamical models. In this study, a statistical data assimilation method, Bayesian filtering, is presented. Its performance is examined with a dynamical model of(More)
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