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Combination of adsorption by porous CaCO(3) microparticles and encapsulation by polyelectrolyte multilayers via the layer-by-layer (LbL) self-assembly was proposed for sustained drug release. Firstly, porous calcium carbonate microparticles with an average diameter of 5 microm were prepared for loading a model drug, ibuprofen (IBU). Adsorption of IBU into(More)
Acid mine drainage (AMD) is an extreme environment, usually with low pH and high concentrations of metals. Although the phylogenetic diversity of AMD microbial communities has been examined extensively, little is known about their functional gene diversity and metabolic potential. In this study, a comprehensive functional gene array (GeoChip 2.0) was used(More)
In the present work, hydrophilic monomer acrylamide (AM) was copolymerized with N-isopropylacrylamide (NIPAm) in an aqueous hectorite clay suspension to prepare PNIPAm-PAM-clay nanocomposite hydrogels (NC gels). With increasing AM content, the elongation at break of the copolymerized NC gels increased but the strength as well as the hysteresis during the(More)
Self-healing hydrogels were proposed to be used as biomaterials, because of the capability of spontaneously healing injury, but most of the reported self-healing hydrogels do not possess high mechanical strength and fast self-healing at the same time. Herein, we prepared graphene oxide (GO)-hectorite clay-poly(N,N-dimethylacrylamide) (PDMAA) hybrid(More)
Congenital diseases caused by abnormal development of the cranial neural crest usually present craniofacial malformations and heart defects while the precise mechanism is not fully understood. Here, we show that the zebrafish eif3ba mutant caused by pseudo-typed retrovirus insertion exhibited a similar phenotype due to the hypogenesis of cranial neural(More)
The molecular diversities of the microbial communities from four sites impacted by acid mine drainage (AMD) at Dexing Copper Mine in Jiangxi province of China were studied using 16S rRNA sequences and gyrB sequences. Of the four sampled sites, each habitat exhibited distinct geochemical characteristics and the sites were linked geographically allowing us to(More)
Indomethacin (IDM) microcrystals sized 5 approximately 10 microm were directly encapsulated with nature polysaccharides chitosan (CHI) and sodium alginate (ALG) through layer-by-layer (LbL) self-assembly. Due to partial dissolution of IDM in the deposition solution, the retention of the IDM microcrystals gradually decreased with increasing deposition times(More)
Polysaccharide multilayer nanocapsules have been fabricated in aqueous media by the layer-by-layer self-assembly of chitosan (CHI) and sodium alginate (ALG) on monodisperse polystyrene (PS) nanoparticles with a diameter of 180 nm as template, followed by removal of the templates through dissolving in THF. The pH and added salt concentration of the(More)
Novel hybrid alginate hydrogel beads with shells of porous CaCO3 microparticles were fabricated by templating water-in-oil emulsion and subsequent in situ gelation. Porous CaCO3 microparticles were self-assembled at interfaces of water-in-oil emulsion. Water droplets containing alginate in the emulsion were subsequently in situ gelated by Ca2+ released from(More)
Polysaccharide multilayer microcapsules were fabricated in aqueous media by the layer-by-layer self-assembly of chitosan (CHI) and sodium alginate (ALG) on melamine formaldehyde (MF) microparticles of 2.1 microm diameter as templates, followed by removal of the templates through dissolving at low pH. The loading process was observed with the confocal laser(More)