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C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms
The molecular understanding of autophagy has originated almost exclusively from yeast genetic studies. Little is known about essential autophagy components specific to higher eukaryotes. Here weExpand
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The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.
PtdIns(3)P plays critical roles in the autophagy pathway. However, little is known about how PtdIns(3)P effectors act with autophagy proteins in autophagosome formation. Here we identified anExpand
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Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.
Epigenetic modifications are thought to be important for gene expression changes during development and aging. However, besides the Sir2 histone deacetylase in somatic tissues and H3K4 trimethylationExpand
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The C. elegans CBFbeta homolog, BRO-1, regulates the proliferation, differentiation and specification of the stem cell-like seam cell lineages.
The RUNX/CBFbeta heterodimeric transcription factor plays an important role in regulating cell proliferation and differentiation in a variety of developmental contexts. Aberrant function of Runx andExpand
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The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells.
Stem cells undergo symmetric and asymmetric division to maintain the dynamic equilibrium of the stem cell pool and also to generate a variety of differentiated cells. The homeostatic mechanismExpand
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The scaffold protein EPG-7 links cargo–receptor complexes with the autophagic assembly machinery
To increase the efficiency of aggrephagy, specific scaffold proteins such as EPG-7 endow cargo specificity and link cargo–receptor complexes to the autophagic machinery.
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The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans
Like other biological processes, aging is regulated by genetic pathways. However, it remains largely unknown whether aging is determined by an innate programmed timing mechanism and, if so, how thisExpand
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Genome‐wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development
The mechanisms that coordinate the regulation of autophagy with developmental signaling during multicellular organism development remain largely unknown. Here, we show that impaired function ofExpand
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The Caenorhabditis elegans PcG-like Gene sop-2 Regulates the Temporal and Sexual Specificities of Cell Fates
How spatial, temporal, and sexual specific cues are integrated to specify distinct cell fates during multicellular organism development is largely unknown. Here we demonstrate that the CaenorhabditisExpand
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The temporally regulated transcription factor sel-7 controls developmental timing in C. elegans.
The temporal sequence of cell division and differentiation is explicitly controlled for succession and synchrony of developmental events. In this study we describe how the Caenorhabditis elegans geneExpand
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