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An increased risk of HIV-1 associated dementia (HAD) has been observed in patients abusing methamphetamine (METH). Since both HIV viral proteins (gp120, Tat) and METH induce oxidative stress, drug abusing patients are at a greater risk of oxidative stress-induced damage. The objective of this study was to determine if N-acetylcysteine amide (NACA) protects(More)
Oxidative stress plays an important role in neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Methamphetamine (METH) is an amphetamine analog that causes degeneration of the dopaminergic system in mammals and subsequent oxidative stress. In our present study, we have used immortalized human brain microvascular endothelial(More)
BACKGROUND Most emerging health threats are of zoonotic origin. For the overwhelming majority, their causative agents are RNA viruses which include but are not limited to HIV, Influenza, SARS, Ebola, Dengue, and Hantavirus. Of increasing importance therefore is a better understanding of global viral diversity to enable better surveillance and prediction of(More)
Modeling and simulating the effects of human factors on landscape change remain as challenges for ecological studies. In this paper, we present a dynamic landscape simulation (DLS) approach to elucidate human-induced landscape changes for a 5104 km 2 study area within the Chicago metropolitan region. The DLS consists of an urban growth simulation submodel(More)
—Breast cancer is a common form of cancer diagnosed in women. Clustered microcalcifications(MCs) in mammograms is one of the important early sign. Their accurate detection is a key problem in computer aided detection (CDAe). In this paper, a novel approach based on the recently developed machine learning technique-twin support vector machines (TWSVM) to(More)
Measles virus is a negative-sense, single-stranded RNA virus within the Mononegavirales order,which includes several human pathogens, including rabies, Ebola, Nipah, and Hendra viruses. The measles virus nucleoprotein consists of a structured N-terminal domain, and of an intrinsically disordered C-terminal domain, N(TAIL) (aa 401-525), which undergoes(More)
—In this paper, a novel algorithm for mammographic images enhancement and denoising based on Multiscale Geometric Analysis (MGA) is proposed. Firstly mammograms are decomposed into different scales and directional subbands using Nonsubsampled Contourlet Transform (NSCT). After modeling the coefficients of each directional subbands using Generalized Gaussian(More)
—In this paper we discuss a new approach for the detection of clustered microcalcifications (MCs) in mammograms. MCs are an important early sign of breast cancer in women. Their accurate detection is a key issue in computer aided detection scheme. To improve the performance of detection, we propose a Bagging and Boosting based twin support vector machine(More)
Zooplankton biomass in Chesapeake Bay was estimated with an optical plankton counter mounted on a towed body (Scanfish). Normalized zooplankton biomass size spectra were calculated for three Bay regions three times a year across 4 yr. Zooplankton biomass was maximum during April, and the zooplankton size at peak biomass was large compared with July and(More)